Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity

Luis Flores Horgue, Alexis Assens, Leon Fodoulian, Leonardo Marconi, Joël Tuberosa, Alexander Haider, Madlaina Boillat, Alan Carleton () and Ivan Rodriguez ()
Additional contact information
Luis Flores Horgue: University of Geneva
Alexis Assens: University of Geneva
Leon Fodoulian: University of Geneva
Leonardo Marconi: University of Geneva
Joël Tuberosa: University of Geneva
Alexander Haider: University of Geneva
Madlaina Boillat: University of Geneva
Alan Carleton: University of Geneva
Ivan Rodriguez: University of Geneva

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of the parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of mouse olfactory sensory neuron populations are already divergent, specific to the olfactory receptor they express, and are associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to reprogramming via the modulation of transcription. These findings highlight a broad range of sensory neuron identities that are present at rest and that adapt to the experience of the individual, thus adding to the complexity and flexibility of sensory coding.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-30511-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30511-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-30511-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().