Characterisation of a nucleo-adhesome

Adam Byron (), Billie G. C. Griffith, Ana Herrero, Alexander E. P. Loftus, Emma S. Koeleman, Linda Kogerman, John C. Dawson, Niamh McGivern, Jayne Culley, Graeme R. Grimes, Bryan Serrels, Alex Kriegsheim, Valerie G. Brunton and Margaret C. Frame
Additional contact information
Adam Byron: University of Edinburgh
Billie G. C. Griffith: University of Edinburgh
Ana Herrero: University of Edinburgh
Alexander E. P. Loftus: University of Edinburgh
Emma S. Koeleman: University of Edinburgh
Linda Kogerman: University of Edinburgh
John C. Dawson: University of Edinburgh
Niamh McGivern: University of Edinburgh
Jayne Culley: University of Edinburgh
Graeme R. Grimes: University of Edinburgh
Bryan Serrels: University of Edinburgh
Alex Kriegsheim: University of Edinburgh
Valerie G. Brunton: University of Edinburgh
Margaret C. Frame: University of Edinburgh

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localise to the nucleus, and conversely, we now report that nuclear proteomes contain a class of adhesome components that localise to the nucleus. We here define a nucleo-adhesome, providing experimental evidence for a remarkable scale of nuclear localisation of adhesion proteins, establishing a framework for interrogating nuclear adhesion protein functions. Adding to nuclear FAK’s known roles in regulating transcription, we now show that nuclear FAK regulates expression of many adhesion-related proteins that localise to the nucleus and that nuclear FAK binds to the adhesome component and nuclear protein Hic-5. FAK and Hic-5 work together in the nucleus, co-regulating a subset of genes transcriptionally. We demonstrate the principle that there are subcomplexes of nuclear adhesion proteins that cooperate to control transcription.

Date: 2022
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DOI: 10.1038/s41467-022-30556-5

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