Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

Jing Zou, Chaitanya Kurhade, Hongjie Xia, Mingru Liu, Xuping Xie (), Ping Ren () and Pei-Yong Shi ()
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Jing Zou: University of Texas Medical Branch
Chaitanya Kurhade: University of Texas Medical Branch
Hongjie Xia: University of Texas Medical Branch
Mingru Liu: University of Texas Medical Branch
Xuping Xie: University of Texas Medical Branch
Ping Ren: University of Texas Medical Branch
Pei-Yong Shi: University of Texas Medical Branch

Nature Communications, 2022, vol. 13, issue 1, 1-5

Abstract: Abstract The Omicron SARS-CoV-2 has several distinct sublineages, among which sublineage BA.1 is responsible for the initial Omicron surge and is now being replaced by BA.2 worldwide, whereas BA.3 is currently at a low frequency. The ongoing BA.1-to-BA.2 replacement underscores the importance to understand the cross-neutralization among the three Omicron sublineages. Here we test the neutralization of BA.1-infected human sera against BA.2, BA.3, and USA/WA1-2020 (a strain isolated in late January 2020). The BA.1-infected sera neutralize BA.1, BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2s with geometric mean titers (GMTs) of 445, 107, 102, and 16, respectively. Thus, the neutralizing GMTs against heterologous BA.2, BA.3, and USA/WA1-2020 are 4.2-, 4.4-, and 28.4-fold lower than the GMT against homologous BA.1, respectively. These findings have implications in COVID-19 vaccine strategy.

Date: 2022
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DOI: 10.1038/s41467-022-30580-5

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