Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts

Hexia Guo, Wubin Bai (), Wei Ouyang, Yihan Liu, Changsheng Wu, Yameng Xu, Yang Weng, Hao Zang, Yiming Liu, Lauren Jacobson, Ziying Hu, Yihang Wang, Hany M. Arafa, Quansan Yang, Di Lu, Shuo Li, Lin Zhang, Xun Xiao, Abraham Vázquez-Guardado, Joanna Ciatti, Elizabeth Dempsey, Nayereh Ghoreishi-Haack, Emily A. Waters, Chad R. Haney, Amanda M. Westman, Matthew R. MacEwan, Mitchell A. Pet () and John A. Rogers ()
Additional contact information
Hexia Guo: Northwestern University
Wubin Bai: Northwestern University
Wei Ouyang: Northwestern University
Yihan Liu: University of North Carolina at Chapel Hill
Changsheng Wu: Northwestern University
Yameng Xu: Washington University in St. Louis
Yang Weng: Northwestern University
Hao Zang: Northwestern University
Yiming Liu: Northwestern University
Lauren Jacobson: Washington University School of Medicine
Ziying Hu: Northwestern University
Yihang Wang: University of North Carolina at Chapel Hill
Hany M. Arafa: Northwestern University
Quansan Yang: Northwestern University
Di Lu: Northwestern University
Shuo Li: Northwestern University
Lin Zhang: University of North Carolina at Chapel Hill
Xun Xiao: University of North Carolina at Chapel Hill
Abraham Vázquez-Guardado: Northwestern University
Joanna Ciatti: Northwestern University
Elizabeth Dempsey: Northwestern University
Nayereh Ghoreishi-Haack: Northwestern University
Emily A. Waters: Northwestern University
Chad R. Haney: Northwestern University
Amanda M. Westman: Washington University School of Medicine
Matthew R. MacEwan: Washington University School of Medicine
Mitchell A. Pet: Washington University School of Medicine
John A. Rogers: Northwestern University

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract Continuous, real-time monitoring of perfusion after microsurgical free tissue transfer or solid organ allotransplantation procedures can facilitate early diagnosis of and intervention for anastomotic thrombosis. Current technologies including Doppler systems, cutaneous O2-sensing probes, and fluorine magnetic resonance imaging methods are limited by their intermittent measurements, requirements for skilled personnel, indirect interfaces, and/or their tethered connections. This paper reports a wireless, miniaturized, minimally invasive near-infrared spectroscopic system designed for uninterrupted monitoring of local-tissue oxygenation. A bioresorbable barbed structure anchors the probe stably at implantation sites for a time period matched to the clinical need, with the ability for facile removal afterward. The probe connects to a skin-interfaced electronic module for wireless access to essential physiological parameters, including local tissue oxygenation, pulse oxygenation, and heart rate. In vitro tests and in vivo studies in porcine flap and kidney models demonstrate the ability of the system to continuously measure oxygenation with high accuracy and sensitivity.

Date: 2022
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DOI: 10.1038/s41467-022-30594-z

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