Peptide nano-blanket impedes fibroblasts activation and subsequent formation of pre-metastatic niche

Yi Zhou, Peng Ke, Xiaoyan Bao, Honghui Wu, Yiyi Xia, Zhentao Zhang, Haiqing Zhong, Qi Dai, Linjie Wu, Tiantian Wang, Mengting Lin, Yaosheng Li, Xinchi Jiang, Qiyao Yang, Yiying Lu, Xincheng Zhong, Min Han () and Jianqing Gao ()
Additional contact information
Yi Zhou: Zhejiang University
Peng Ke: Zhejiang University
Xiaoyan Bao: Zhejiang University
Honghui Wu: Zhejiang University
Yiyi Xia: Zhejiang University
Zhentao Zhang: Zhejiang University
Haiqing Zhong: Zhejiang University
Qi Dai: Zhejiang University
Linjie Wu: Zhejiang University
Tiantian Wang: Zhejiang University
Mengting Lin: Zhejiang University
Yaosheng Li: Zhejiang University
Xinchi Jiang: Zhejiang University
Qiyao Yang: Zhejiang University
Yiying Lu: Zhejiang University
Xincheng Zhong: Zhejiang University
Min Han: Zhejiang University
Jianqing Gao: Zhejiang University

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract There is evidence to suggest that the primary tumor induces the formation of a pre-metastatic niche in distal organs by stimulating the production of pro-metastatic factors. Given the fundamental role of the pre-metastatic niche in the development of metastases, interruption of its formation would be a promising strategy to take early action against tumor metastasis. Here we report an enzyme-activated assembled peptide FR17 that can serve as a “flame-retarding blanket” in the pre-metastatic niche specifically to extinguish the “fire” of tumor-supportive microenvironment adaption. We show that the in-situ assembled peptide nano-blanket inhibits fibroblasts activation, suppressing the remodeling of the metastasis-supportive host stromal tissue, and reversing vascular destabilization and angiogenesis. Furthermore, we demonstrate that the nano-blanket prevents the recruitment of myeloid cells to the pre-metastatic niche, regulating the immune-suppressive microenvironment. We show that FR17 administration effectively inhibits the formation of the pulmonary pre-metastatic niche and postoperative metastasis, offering a therapeutic strategy against pre-metastatic niche formation.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-022-30634-8 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30634-8

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-30634-8

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().