Open-source personal pipetting robots with live-cell incubation and microscopy compatibility

Philip Dettinger (), Tobias Kull, Geethika Arekatla, Nouraiz Ahmed, Yang Zhang, Florin Schneiter, Arne Wehling, Daniel Schirmacher, Shunsuke Kawamura, Dirk Loeffler and Timm Schroeder ()
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Philip Dettinger: ETH Zurich
Tobias Kull: ETH Zurich
Geethika Arekatla: ETH Zurich
Nouraiz Ahmed: ETH Zurich
Yang Zhang: ETH Zurich
Florin Schneiter: ETH Zurich
Arne Wehling: ETH Zurich
Daniel Schirmacher: ETH Zurich
Shunsuke Kawamura: ETH Zurich
Dirk Loeffler: ETH Zurich
Timm Schroeder: ETH Zurich

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract Liquid handling robots have the potential to automate many procedures in life sciences. However, they are not in widespread use in academic settings, where funding, space and maintenance specialists are usually limiting. In addition, current robots require lengthy programming by specialists and are incompatible with most academic laboratories with constantly changing small-scale projects. Here, we present the Pipetting Helper Imaging Lid (PHIL), an inexpensive, small, open-source personal liquid handling robot. It is designed for inexperienced users, with self-production from cheap commercial and 3D-printable components and custom control software. PHIL successfully automates pipetting (incl. aspiration) for e.g. tissue immunostainings and stimulations of live stem and progenitor cells during time-lapse microscopy using 3D printed peristaltic pumps. PHIL is cheap enough to put a personal pipetting robot within the reach of most labs and enables users without programming skills to easily automate a large range of experiments.

Date: 2022
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DOI: 10.1038/s41467-022-30643-7

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