Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine

Chaitanya Kurhade, Jing Zou, Hongjie Xia, Hui Cai, Qi Yang, Mark Cutler, David Cooper, Alexander Muik, Kathrin U. Jansen, Xuping Xie (), Kena A. Swanson () and Pei‑Yong Shi ()
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Chaitanya Kurhade: University of Texas Medical Branch
Jing Zou: University of Texas Medical Branch
Hongjie Xia: University of Texas Medical Branch
Hui Cai: Pfizer Vaccine Research and Development, Pearl River
Qi Yang: Pfizer Vaccine Research and Development, Pearl River
Mark Cutler: Pfizer Vaccine Research and Development, Pearl River
David Cooper: Pfizer Vaccine Research and Development, Pearl River
Alexander Muik: BioNTech
Kathrin U. Jansen: Pfizer Vaccine Research and Development, Pearl River
Xuping Xie: University of Texas Medical Branch
Kena A. Swanson: Pfizer Vaccine Research and Development, Pearl River
Pei‑Yong Shi: University of Texas Medical Branch

Nature Communications, 2022, vol. 13, issue 1, 1-4

Abstract: Abstract The newly emerged Omicron SARS-CoV-2 has several distinct sublineages including BA.1, BA.2, and BA.3. BA.1 accounts for the initial surge and is being replaced by BA.2, whereas BA.3 is at a low prevalence at this time. Here we report the neutralization of BNT162b2-vaccinated sera (collected 1 month after dose 3) against the three Omicron sublineages. To facilitate the neutralization testing, we have engineered the complete BA.1, BA.2, or BA.3 spike into an mNeonGreen USA-WA1/2020 SRAS-CoV-2. All BNT162b2-vaccinated sera neutralize USA-WA1/2020, BA.1-, BA.2-, and BA.3-spike SARS-CoV-2s with titers of >20; the neutralization geometric mean titers (GMTs) against the four viruses are 1211, 336, 300, and 190, respectively. Thus, the BA.1-, BA.2-, and BA.3-spike SARS-CoV-2s are 3.6-, 4.0-, and 6.4-fold less efficiently neutralized than the USA-WA1/2020, respectively. Our data have implications in vaccine strategy and understanding the biology of Omicron sublineages.

Date: 2022
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DOI: 10.1038/s41467-022-30681-1

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