A lncRNA signature associated with tumor immune heterogeneity predicts distant metastasis in locoregionally advanced nasopharyngeal carcinoma

Ye-Lin Liang, Yuan Zhang, Xi-Rong Tan, Han Qiao, Song-Ran Liu, Ling-Long Tang, Yan-Ping Mao, Lei Chen, Wen-Fei Li, Guan-Qun Zhou, Yin Zhao, Jun-Yan Li, Qian Li, Sheng-Yan Huang, Sha Gong, Zi-Qi Zheng, Zhi-Xuan Li, Ying Sun, Wei Jiang (), Jun Ma (), Ying-Qin Li () and Na Liu ()
Additional contact information
Ye-Lin Liang: Sun Yat-sen University Cancer Center
Yuan Zhang: Sun Yat-sen University Cancer Center
Xi-Rong Tan: Sun Yat-sen University Cancer Center
Han Qiao: Sun Yat-sen University Cancer Center
Song-Ran Liu: Sun Yat-sen University Cancer Center
Ling-Long Tang: Sun Yat-sen University Cancer Center
Yan-Ping Mao: Sun Yat-sen University Cancer Center
Lei Chen: Sun Yat-sen University Cancer Center
Wen-Fei Li: Sun Yat-sen University Cancer Center
Guan-Qun Zhou: Sun Yat-sen University Cancer Center
Yin Zhao: Sun Yat-sen University Cancer Center
Jun-Yan Li: Sun Yat-sen University Cancer Center
Qian Li: Sun Yat-sen University Cancer Center
Sheng-Yan Huang: Sun Yat-sen University Cancer Center
Sha Gong: Sun Yat-sen University Cancer Center
Zi-Qi Zheng: Sun Yat-sen University Cancer Center
Zhi-Xuan Li: Sun Yat-sen University Cancer Center
Ying Sun: Sun Yat-sen University Cancer Center
Wei Jiang: Affiliated Hospital of Guilin Medical University
Jun Ma: Sun Yat-sen University Cancer Center
Ying-Qin Li: Sun Yat-sen University Cancer Center
Na Liu: Sun Yat-sen University Cancer Center

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract Increasing evidence has revealed the roles of long noncoding RNAs (lncRNAs) as tumor biomarkers. Here, we introduce an immune-associated nine-lncRNA signature for predicting distant metastasis in locoregionally advanced nasopharyngeal carcinoma (LA-NPC). The nine lncRNAs are identified through microarray profiling, followed by RT–qPCR validation and selection using a machine learning method in the training cohort (n = 177). This nine-lncRNA signature classifies patients into high and low risk groups, which have significantly different distant metastasis-free survival. Validations in the Guangzhou internal (n = 177) and Guilin external (n = 150) cohorts yield similar results, confirming that the signature is an independent risk factor for distant metastasis and outperforms anatomy-based metrics in identifying patients with high metastatic risk. Integrative analyses show that this nine-lncRNA signature correlates with immune activity and lymphocyte infiltration, which is validated by digital pathology. Our results suggest that the immune-associated nine-lncRNA signature can serve as a promising biomarker for metastasis prediction in LA-NPC.

Date: 2022
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DOI: 10.1038/s41467-022-30709-6

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