The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases

Zengliang Jiang, Lai-bao Zhuo, Yan He, Yuanqing Fu, Luqi Shen, Fengzhe Xu, Wanglong Gou, Zelei Miao, Menglei Shuai, Yuhui Liang, Congmei Xiao, Xinxiu Liang, Yunyi Tian, Jiali Wang, Jun Tang, Kui Deng, Hongwei Zhou (), Yu-ming Chen () and Ju-Sheng Zheng ()
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Zengliang Jiang: Westlake University
Lai-bao Zhuo: Sun Yat-sen University
Yan He: Southern Medical University
Yuanqing Fu: Westlake University
Luqi Shen: Westlake University
Fengzhe Xu: Westlake University
Wanglong Gou: Westlake University
Zelei Miao: Westlake University
Menglei Shuai: Westlake University
Yuhui Liang: Westlake University
Congmei Xiao: Westlake University
Xinxiu Liang: Westlake University
Yunyi Tian: Westlake University
Jiali Wang: Westlake University
Jun Tang: Westlake University
Kui Deng: Westlake University
Hongwei Zhou: Southern Medical University
Yu-ming Chen: Sun Yat-sen University
Ju-Sheng Zheng: Westlake University

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract Evidence from human cohorts indicates that chronic insomnia is associated with higher risk of cardiometabolic diseases (CMD), yet whether gut microbiota plays a role is unclear. Here, in a longitudinal cohort (n = 1809), we find that the gut microbiota-bile acid axis may link the positive association between chronic insomnia and CMD. Ruminococcaceae UCG-002 and Ruminococcaceae UCG-003 are the main genera mediating the positive association between chronic insomnia and CMD. These results are also observed in an independent cross-sectional cohort (n = 6122). The inverse associations between those gut microbial biomarkers and CMD are mediated by certain bile acids (isolithocholic acid, muro cholic acid and nor cholic acid). Habitual tea consumption is prospectively associated with the identified gut microbiota and bile acids in an opposite direction compared with chronic insomnia. Our work suggests that microbiota-bile acid axis may be a potential intervention target for reducing the impact of chronic insomnia on cardiometabolic health.

Date: 2022
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DOI: 10.1038/s41467-022-30712-x

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