Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy

Yang Yang, Jinshu Huang, Wei Wei, Qin Zeng, Xipeng Li, Da Xing, Bo Zhou () and Tao Zhang ()
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Yang Yang: South China Normal University
Jinshu Huang: South China University of Technology
Wei Wei: South China Normal University
Qin Zeng: South China Normal University
Xipeng Li: South China Normal University
Da Xing: South China Normal University
Bo Zhou: South China University of Technology
Tao Zhang: South China Normal University

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Phototheranostics based on upconversion nanoparticles (UCNPs) offer the integration of imaging diagnostics and phototherapeutics. However, the programmable control of the photoactivation of imaging and therapy with minimum side effects is challenging due to the lack of ideal switchable UCNPs agents. Here we demonstrate a facile strategy to switch the near infrared emission at 800 nm from rationally designed UCNPs by modulating the irradiation laser into pulse output. We further synthesize a theranostic nanoagent by combining with a photosensitizer and a photoabsorbing agent assembled on the UCNPs. The orthogonal activation of in vivo photoacoustic imaging and photodynamic therapy can be achieved by altering the excitation modes from pulse to continuous-wave output upon a single 980 nm laser. No obvious harmful effects during photoexcitation was identified, suggesting their use for long-term imaging-guidance and phototherapy. This work provides an approach to the orthogonal activation of imaging diagnostics and photodynamic therapeutics.

Date: 2022
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DOI: 10.1038/s41467-022-30713-w

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