A supramolecular photosensitizer derived from an Arene-Ru(II) complex self-assembly for NIR activated photodynamic and photothermal therapy

Gang Xu, Chengwei Li, Chen Chi, Luyan Wu, Yanyan Sun, Jian Zhao (), Xing-Hua Xia () and Shaohua Gou ()
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Gang Xu: Southeast University
Chengwei Li: Southeast University
Chen Chi: Nanjing University
Luyan Wu: Nanjing University
Yanyan Sun: Suzhou University of Science and Technology
Jian Zhao: Southeast University
Xing-Hua Xia: Nanjing University
Shaohua Gou: Southeast University

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Effective photosensitizers are of particular importance for the widespread clinical utilization of phototherapy. However, conventional photosensitizers are usually plagued by short-wavelength absorption, inadequate photostability, low reactive oxygen species (ROS) quantum yields, and aggregation-caused ROS quenching. Here, we report a near-infrared (NIR)-supramolecular photosensitizer (RuDA) via self-assembly of an organometallic Ru(II)-arene complex in aqueous solution. RuDA can generate singlet oxygen (1O2) only in aggregate state, showing distinct aggregation-induced 1O2 generation behavior due to the greatly increased singlet-triplet intersystem crossing process. Upon 808 nm laser irradiation, RuDA with excellent photostability displays efficient 1O2 and heat generation in a 1O2 quantum yield of 16.4% (FDA-approved indocyanine green: ΦΔ = 0.2%) together with high photothermal conversion efficiency of 24.2% (commercial gold nanorods: 21.0%, gold nanoshells: 13.0%). In addition, RuDA-NPs with good biocompatibility can be preferably accumulated at tumor sites, inducing significant tumor regression with a 95.2% tumor volume reduction in vivo during photodynamic therapy. This aggregation enhanced photodynamic therapy provides a strategy for the design of photosensitizers with promising photophysical and photochemical characteristics.

Date: 2022
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DOI: 10.1038/s41467-022-30721-w

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