Microfluidics for understanding model organisms

Nolan Frey, Utku M. Sönmez, Jonathan Minden () and Philip LeDuc ()
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Nolan Frey: Carnegie Mellon University
Utku M. Sönmez: Carnegie Mellon University
Jonathan Minden: Carnegie Mellon University
Philip LeDuc: Carnegie Mellon University

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract New microfluidic systems for whole organism analysis and experimentation are catalyzing biological breakthroughs across many fields, from human health to fundamental biology principles. This perspective discusses recent microfluidic tools to study intact model organisms to demonstrate the tremendous potential for these integrated approaches now and into the future. We describe these microsystems' technical features and highlight the unique advantages for precise manipulation in areas including immobilization, automated alignment, sorting, sensory, mechanical and chemical stimulation, and genetic and thermal perturbation. Our aim is to familiarize technologically focused researchers with microfluidics applications in biology research, while providing biologists an entrée to advanced microengineering techniques for model organisms.

Date: 2022
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DOI: 10.1038/s41467-022-30814-6

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