Altered predictive control during memory suppression in PTSD

Giovanni Leone, Charlotte Postel, Alison Mary, Florence Fraisse, Thomas Vallée, Fausto Viader, Vincent Sayette, Denis Peschanski, Jaques Dayan, Francis Eustache and Pierre Gagnepain ()
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Giovanni Leone: Neuropsychologie et Imagerie de la Mémoire Humaine
Charlotte Postel: Neuropsychologie et Imagerie de la Mémoire Humaine
Alison Mary: Neuropsychologie et Imagerie de la Mémoire Humaine
Florence Fraisse: Neuropsychologie et Imagerie de la Mémoire Humaine
Thomas Vallée: Neuropsychologie et Imagerie de la Mémoire Humaine
Fausto Viader: Neuropsychologie et Imagerie de la Mémoire Humaine
Vincent Sayette: Neuropsychologie et Imagerie de la Mémoire Humaine
Denis Peschanski: CNRS
Jaques Dayan: Neuropsychologie et Imagerie de la Mémoire Humaine
Francis Eustache: Neuropsychologie et Imagerie de la Mémoire Humaine
Pierre Gagnepain: Neuropsychologie et Imagerie de la Mémoire Humaine

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Aberrant predictions of future threat lead to maladaptive avoidance in individuals with post-traumatic stress disorder (PTSD). How this disruption in prediction influences the control of memory states orchestrated by the dorsolateral prefrontal cortex is unknown. We combined computational modeling and brain connectivity analyses to reveal how individuals exposed and nonexposed to the 2015 Paris terrorist attacks formed and controlled beliefs about future intrusive re-experiencing implemented in the laboratory during a memory suppression task. Exposed individuals with PTSD used beliefs excessively to control hippocampal activity during the task. When this predictive control failed, the prediction-error associated with unwanted intrusions was poorly downregulated by reactive mechanisms. This imbalance was linked to higher severity of avoidance symptoms, but not to general disturbances such as anxiety or negative affect. Conversely, trauma-exposed participants without PTSD and nonexposed individuals were able to optimally balance predictive and reactive control during the memory suppression task. These findings highlight a potential pathological mechanism occurring in individuals with PTSD rooted in the relationship between the brain’s predictive and control mechanisms.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30855-x

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DOI: 10.1038/s41467-022-30855-x

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