Perirenal adipose afferent nerves sustain pathological high blood pressure in rats

Peng Li, Boxun Liu, Xiaoguang Wu, Yan Lu, Ming Qiu, Yihui Shen, Yunfan Tian, Chi Liu, Xiru Chen, Chuanxi Yang, Mengqing Deng, Yaqing Wang, Jia Gu, Zhongping Su, Xuguan Chen, Kun Zhao, Yanhui Sheng, Shijiang Zhang, Wei Sun () and Xiangqing Kong ()
Additional contact information
Peng Li: The First Affiliated Hospital of Nanjing Medical University
Boxun Liu: The First Affiliated Hospital of Nanjing Medical University
Xiaoguang Wu: The First Affiliated Hospital of Nanjing Medical University
Yan Lu: The First Affiliated Hospital of Nanjing Medical University
Ming Qiu: The First Affiliated Hospital of Nanjing Medical University
Yihui Shen: The First Affiliated Hospital of Nanjing Medical University
Yunfan Tian: The First Affiliated Hospital of Nanjing Medical University
Chi Liu: The First Affiliated Hospital of Nanjing Medical University
Xiru Chen: The First Affiliated Hospital of Nanjing Medical University
Chuanxi Yang: The First Affiliated Hospital of Nanjing Medical University
Mengqing Deng: The First Affiliated Hospital of Nanjing Medical University
Yaqing Wang: The First Affiliated Hospital of Nanjing Medical University
Jia Gu: The First Affiliated Hospital of Nanjing Medical University
Zhongping Su: The First Affiliated Hospital of Nanjing Medical University
Xuguan Chen: The First Affiliated Hospital of Nanjing Medical University
Kun Zhao: The First Affiliated Hospital of Nanjing Medical University
Yanhui Sheng: The First Affiliated Hospital of Nanjing Medical University
Shijiang Zhang: Cardiovascular Device and Technique Engineering Laboratory of Jiangsu Province
Wei Sun: The First Affiliated Hospital of Nanjing Medical University
Xiangqing Kong: The First Affiliated Hospital of Nanjing Medical University

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract Hypertension is a pathological condition of persistent high blood pressure (BP) of which the underlying neural mechanisms remain obscure. Here, we show that the afferent nerves in perirenal adipose tissue (PRAT) contribute to maintain pathological high BP, without affecting physiological BP. Bilateral PRAT ablation or denervation leads to a long-term reduction of high BP in spontaneous hypertensive rats (SHR), but has no effect on normal BP in control rats. Further, gain- and loss-of-function and neuron transcriptomics studies show that augmented activities and remodeling of L1-L2 dorsal root ganglia neurons are responsible for hypertension in SHR. Moreover, we went on to show that calcitonin gene-related peptide (CGRP) is a key endogenous suppressor of hypertension that is sequestered by pro-hypertensive PRAT in SHRs. Taken together, we identify PRAT afferent nerves as a pro-hypertensive node that sustains high BP via suppressing CGRP, thereby providing a therapeutic target to tackle primary hypertension.

Date: 2022
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DOI: 10.1038/s41467-022-30868-6

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