Waning effectiveness of the third dose of the BNT162b2 mRNA COVID-19 vaccine

Tal Patalon (), Yaki Saciuk, Asaf Peretz, Galit Perez, Yoav Lurie, Yasmin Maor and Sivan Gazit
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Tal Patalon: Kahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services
Yaki Saciuk: Kahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services
Asaf Peretz: Maccabitech Institute for Research and Innovation, Maccabi Healthcare Services
Galit Perez: Maccabitech Institute for Research and Innovation, Maccabi Healthcare Services
Yoav Lurie: Liver unit, Shaare Zedek City Center Campus
Yasmin Maor: Tel Aviv University
Sivan Gazit: Kahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services

Nature Communications, 2022, vol. 13, issue 1, 1-7

Abstract: Abstract The duration of protection of the third (booster) dose of the BioNTech/Pfizer BNT162b2 mRNA Coronavirus Disease 2019 vaccine has been the subject of recent investigations, as global discussions around the necessity and effectiveness of a fourth dose are already underway. By conducting a retrospective study implementing a test-negative case-control design, analyzing 546,924 PCR tests performed throughout January 2022 by 389,265 persons who received at least two doses, we find that the effectiveness in each month-since-vaccination decreases significantly. Compared to those vaccinated five months prior to the outcome period, on August 2021, relative protection against infection waned from 53.4% a month after vaccination to 16.5% three months after vaccination. These results suggest that there is a significant waning of vaccine effectiveness against the Omicron variant of the third dose of the BNT162b2 vaccine within a few months after administration. Additional information could assist to comprehensively estimate the effectiveness of the three-dose-strategy.

Date: 2022
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DOI: 10.1038/s41467-022-30884-6

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