Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging

Yun-Wen Wu, Sen Li, Wei Zheng, Yan-Chu Li, Lu Chen, Yong Zhou, Zuo-Qi Deng, Ge Lin, Heng-Yu Fan () and Qian-Qian Sha ()
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Yun-Wen Wu: MOE Key Laboratory for Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
Sen Li: Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital
Wei Zheng: Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA
Yan-Chu Li: Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital
Lu Chen: MOE Key Laboratory for Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
Yong Zhou: Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital
Zuo-Qi Deng: MOE Key Laboratory for Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
Ge Lin: Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA
Heng-Yu Fan: MOE Key Laboratory for Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
Qian-Qian Sha: Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract A decrease in oocyte developmental potential is a major obstacle for successful pregnancy in women of advanced age. However, the age-related epigenetic modifications associated with dynamic transcriptome changes, particularly meiotic maturation-coupled mRNA clearance, have not been adequately characterized in human oocytes. This study demonstrates a decreased storage of transcripts encoding key factors regulating the maternal mRNA degradome in fully grown oocytes of women of advanced age. A similar defect in meiotic maturation-triggered mRNA clearance is also detected in aged mouse oocytes. Mechanistically, the epigenetic and cytoplasmic aspects of oocyte maturation are synchronized in both the normal development and aging processes. The level of histone H3K4 trimethylation (H3K4me3) is high in fully grown mouse and human oocytes derived from young females but decreased during aging due to the decreased expression of epigenetic factors responsible for H3K4me3 accumulation. Oocyte-specific knockout of the gene encoding CxxC-finger protein 1 (CXXC1), a DNA-binding subunit of SETD1 methyltransferase, causes ooplasm changes associated with accelerated aging and impaired maternal mRNA translation and degradation. These results suggest that a network of CXXC1-maintained H3K4me3, in association with mRNA decay competence, sets a timer for oocyte deterioration and plays a role in oocyte aging in both mouse and human oocytes.

Date: 2022
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DOI: 10.1038/s41467-022-30928-x

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