Mnemonic construction and representation of temporal structure in the hippocampal formation

Jacob L. S. Bellmund (), Lorena Deuker, Nicole D. Montijn and Christian F. Doeller ()
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Jacob L. S. Bellmund: Max Planck Institute for Human Cognitive and Brain Sciences
Lorena Deuker: Radboud University
Nicole D. Montijn: Utrecht University
Christian F. Doeller: Max Planck Institute for Human Cognitive and Brain Sciences

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract The hippocampal-entorhinal region supports memory for episodic details, such as temporal relations of sequential events, and mnemonic constructions combining experiences for inferential reasoning. However, it is unclear whether hippocampal event memories reflect temporal relations derived from mnemonic constructions, event order, or elapsing time, and whether these sequence representations generalize temporal relations across similar sequences. Here, participants mnemonically constructed times of events from multiple sequences using infrequent cues and their experience of passing time. After learning, event representations in the anterior hippocampus reflected temporal relations based on constructed times. Temporal relations were generalized across sequences, revealing distinct representational formats for events from the same or different sequences. Structural knowledge about time patterns, abstracted from different sequences, biased the construction of specific event times. These findings demonstrate that mnemonic construction and the generalization of relational knowledge combine in the hippocampus, consistent with the simulation of scenarios from episodic details and structural knowledge.

Date: 2022
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DOI: 10.1038/s41467-022-30984-3

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