In situ 3D bioprinting with bioconcrete bioink

Mingjun Xie, Yang Shi, Chun Zhang, Mingjie Ge, Jingbo Zhang, Zichen Chen, Jianzhong Fu, Zhijian Xie and Yong He ()
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Mingjun Xie: Zhejiang University
Yang Shi: Zhejiang University School of Medicine
Chun Zhang: Zhejiang University School of Medicine
Mingjie Ge: Zhejiang University School of Medicine
Jingbo Zhang: Zhejiang University
Zichen Chen: Zhejiang University
Jianzhong Fu: Zhejiang University
Zhijian Xie: Zhejiang University School of Medicine
Yong He: Zhejiang University

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract In-situ bioprinting is attractive for directly depositing the therapy bioink at the defective organs to repair them, especially for occupations such as soldiers, athletes, and drivers who can be injured in emergency. However, traditional bioink displays obvious limitations in its complex operation environments. Here, we design a bioconcrete bioink with electrosprayed cell-laden microgels as the aggregate and gelatin methacryloyl (GelMA) precursor solution as the cement. Promising printability is guaranteed with a wide temperature range benefiting from robust rheological properties of photocrosslinked microgel aggregate and fluidity of GelMA cement. Composite components simultaneously self-adapt to biocompatibility and different tissue mechanical microenvironment. Strong binding on tissue-hydrogel interface is achieved by hydrogen bonds and friction when the cement is photocrosslinked. This bioink owns good portability and can be easily prepared in urgent accidents. Meanwhile, microgels can be cultured to mini tissues and then mixed as bioink aggregates, indicating our bioconcrete can be functionalized faster than normal bioinks. The cranial defects repair results verify the superiority of this bioink and its potential in clinical settings required in in-situ treatment.

Date: 2022
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DOI: 10.1038/s41467-022-30997-y

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