A single-cell transcriptomic atlas characterizes the silk-producing organ in the silkworm

Yan Ma, Wenhui Zeng, Yongbing Ba, Qin Luo, Yao Ou, Rongpeng Liu, Jingwen Ma, Yiyun Tang, Jie Hu, Haomiao Wang, Xuan Tang, Yuanyuan Mu, Qingjun Li, Yuqin Chen, Yiting Ran, Zhonghuai Xiang and Hanfu Xu ()
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Yan Ma: Southwest University
Wenhui Zeng: Southwest University
Yongbing Ba: Shanghai OE Biotech. Co., Ltd.
Qin Luo: Southwest University
Yao Ou: Southwest University
Rongpeng Liu: Southwest University
Jingwen Ma: Southwest University
Yiyun Tang: Southwest University
Jie Hu: Southwest University
Haomiao Wang: Southwest University
Xuan Tang: Shanghai OE Biotech. Co., Ltd.
Yuanyuan Mu: Southwest University
Qingjun Li: Southwest University
Yuqin Chen: Southwest University
Yiting Ran: Southwest University
Zhonghuai Xiang: Southwest University
Hanfu Xu: Southwest University

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract The silk gland of the domesticated silkworm Bombyx mori, is a remarkable organ that produces vast amounts of silk with exceptional properties. Little is known about which silk gland cells execute silk protein synthesis and its precise spatiotemporal control. Here, we use single-cell RNA sequencing to build a comprehensive cell atlas of the silkworm silk gland, consisting of 14,972 high-quality cells representing 10 distinct cell types, in three early developmental stages. We annotate all 10 cell types and determine their distributions in each region of the silk gland. Additionally, we decode the developmental trajectory and gene expression status of silk gland cells. Finally, we discover marker genes involved in the regulation of silk gland development and silk protein synthesis. Altogether, this work reveals the heterogeneity of silkworm silk gland cells and their gene expression dynamics, affording a deeper understanding of silk-producing organs at the single-cell level.

Date: 2022
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DOI: 10.1038/s41467-022-31003-1

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