Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders

Shahram Bahrami (), Kaja Nordengen, Alexey A. Shadrin, Oleksandr Frei, Dennis Meer, Anders M. Dale, Lars T. Westlye, Ole A. Andreassen and Tobias Kaufmann ()
Additional contact information
Shahram Bahrami: University of Oslo
Kaja Nordengen: University of Oslo
Alexey A. Shadrin: University of Oslo
Oleksandr Frei: University of Oslo
Dennis Meer: University of Oslo
Anders M. Dale: University of California
Lars T. Westlye: University of Oslo
Ole A. Andreassen: University of Oslo
Tobias Kaufmann: University of Oslo

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract Despite its major role in complex human functions across the lifespan, most notably navigation, learning and memory, much of the genetic architecture of the hippocampal formation is currently unexplored. Here, through multivariate genome-wide association analysis in volumetric data from 35,411 white British individuals, we reveal 177 unique genetic loci with distributed associations across the hippocampal formation. We identify genetic overlap with eight brain disorders with typical onset at different stages of life, where common genes suggest partly age- and disorder-independent mechanisms underlying hippocampal pathology.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-31086-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31086-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-31086-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().