The architecture and operating mechanism of a cnidarian stinging organelle

Ahmet Karabulut (), Melainia McClain, Boris Rubinstein, Keith Z. Sabin, Sean A. McKinney and Matthew C. Gibson ()
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Ahmet Karabulut: Stowers Institute for Medical Research
Melainia McClain: Stowers Institute for Medical Research
Boris Rubinstein: Stowers Institute for Medical Research
Keith Z. Sabin: Stowers Institute for Medical Research
Sean A. McKinney: Stowers Institute for Medical Research
Matthew C. Gibson: Stowers Institute for Medical Research

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract The stinging organelles of jellyfish, sea anemones, and other cnidarians, known as nematocysts, are remarkable cellular weapons used for both predation and defense. Nematocysts consist of a pressurized capsule containing a coiled harpoon-like thread. These structures are in turn built within specialized cells known as nematocytes. When triggered, the capsule explosively discharges, ejecting the coiled thread which punctures the target and rapidly elongates by turning inside out in a process called eversion. Due to the structural complexity of the thread and the extreme speed of discharge, the precise mechanics of nematocyst firing have remained elusive7. Here, using a combination of live and super-resolution imaging, 3D electron microscopy, and genetic perturbations, we define the step-by-step sequence of nematocyst operation in the model sea anemone Nematostella vectensis. This analysis reveals the complex biomechanical transformations underpinning the operating mechanism of nematocysts, one of nature’s most exquisite biological micro-machines. Further, this study will provide insight into the form and function of related cnidarian organelles and serve as a template for the design of bioinspired microdevices.

Date: 2022
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DOI: 10.1038/s41467-022-31090-0

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