Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy

Weicheng Shen, Tingting Hu, Xueyan Liu, Jiajia Zha, Fanqi Meng, Zhikang Wu, Zhuolin Cui, Yu Yang, Hai Li, Qinghua Zhang, Lin Gu, Ruizheng Liang () and Chaoliang Tan ()
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Weicheng Shen: Beijing University of Chemical Technology
Tingting Hu: Beijing University of Chemical Technology
Xueyan Liu: Beijing University of Chemical Technology
Jiajia Zha: City University of Hong Kong
Fanqi Meng: Chinese Academy of Sciences
Zhikang Wu: Nanjing Tech University (NanjingTech), 30 South Puzhu Road
Zhuolin Cui: Beijing University of Chemical Technology
Yu Yang: Beijing University of Chemical Technology
Hai Li: Nanjing Tech University (NanjingTech), 30 South Puzhu Road
Qinghua Zhang: Chinese Academy of Sciences
Lin Gu: Chinese Academy of Sciences
Ruizheng Liang: Beijing University of Chemical Technology
Chaoliang Tan: City University of Hong Kong

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Although two-dimensional (2D) layered double hydroxides (LDHs) have been widely used as efficient nanoagents for biological diagnosis and treatment, they have been found to be inert as photosensitizers (PSs) for photodynamic therapy (PDT). Herein, we report the defect engineering of ultrathin 2D CoMo-LDH and NiMo-LDH nanosheets as highly active inorganic PSs for PDT in the third near-infrared (NIR-III) window. Hydrothermal-synthesized 2D CoMo-LDH and NiMo-LDH nanosheets are etched via a simple acid treatment to obtain defect-rich CoMo-LDH and NiMo-LDH nanosheets. Importantly, the defect-rich CoMo-LDH nanosheets exhibit much higher activity (~97 times) for generation of reactive oxygen species than that of the pristine CoMo-LDH nanosheets under a NIR-III 1567 nm laser irradiation. Therefore, after modification with polyethylene glycol, the defect-rich CoMo-LDH nanosheets can be used as an efficient inorganic PS for PDT to efficiently induce cancer cells apoptosis in vitro and eradicate tumors in vivo under 1567 nm laser irradiation.

Date: 2022
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DOI: 10.1038/s41467-022-31106-9

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