Innate immune responses against the fungal pathogen Candida auris

Yuanyuan Wang, Yun Zou, Xiaoqing Chen, Hao Li, Zhe Yin, Baocai Zhang, Yongbin Xu, Yiquan Zhang, Rulin Zhang, Xinhua Huang, Wenhui Yang, Chaoyue Xu, Tong Jiang, Qinyu Tang, Zili Zhou, Ying Ji, Yingqi Liu, Lingfei Hu, Jia Zhou, Yao Zhou, Jingjun Zhao, Ningning Liu, Guanghua Huang, Haishuang Chang, Wenxia Fang, Changbin Chen () and Dongsheng Zhou ()
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Yuanyuan Wang: Chinese Academy of Sciences
Yun Zou: Chinese Academy of Sciences
Xiaoqing Chen: Chinese Academy of Sciences
Hao Li: Shanghai Jiao Tong University School of Medicine
Zhe Yin: Beijing Institute of Microbiology and Epidemiology
Baocai Zhang: Chinese Academy of Sciences
Yongbin Xu: Shanghai University of Traditional Chinese Medicine
Yiquan Zhang: Jiangnan University
Rulin Zhang: Shanghai Jiao Tong University School of Medicine
Xinhua Huang: Chinese Academy of Sciences
Wenhui Yang: Beijing Institute of Microbiology and Epidemiology
Chaoyue Xu: Chinese Academy of Sciences
Tong Jiang: Chinese Academy of Sciences
Qinyu Tang: Tongji University School of Medicine
Zili Zhou: Chinese Academy of Sciences
Ying Ji: Chinese Academy of Sciences
Yingqi Liu: Gannan Medical University
Lingfei Hu: Beijing Institute of Microbiology and Epidemiology
Jia Zhou: Shanghai Jiaotong University School of Medicine
Yao Zhou: Guangxi Academy of Sciences
Jingjun Zhao: Tongji University School of Medicine
Ningning Liu: Shanghai Jiaotong University School of Medicine
Guanghua Huang: Fudan University
Haishuang Chang: Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine
Wenxia Fang: Guangxi Academy of Sciences
Changbin Chen: Chinese Academy of Sciences
Dongsheng Zhou: Beijing Institute of Microbiology and Epidemiology

Nature Communications, 2022, vol. 13, issue 1, 1-20

Abstract: Abstract Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects of C. auris, its interaction with the host immune system is only now beginning to be investigated in-depth. Here, we compare the innate immune responses induced by C. auris BJCA001 and Candida albicans SC5314 in vitro and in vivo. Our results indicate that C. auris BJCA001 appears to be less immunoinflammatory than C. albicans SC5314, and this differential response correlates with structural features of the cell wall.

Date: 2022
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DOI: 10.1038/s41467-022-31201-x

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