Structural basis for the activation and ligand recognition of the human oxytocin receptor

Yann Waltenspühl, Janosch Ehrenmann, Santiago Vacca, Cristian Thom, Ohad Medalia and Andreas Plückthun ()
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Yann Waltenspühl: University of Zürich
Janosch Ehrenmann: University of Zürich
Santiago Vacca: University of Zürich
Cristian Thom: University of Zürich
Ohad Medalia: University of Zürich
Andreas Plückthun: University of Zürich

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract The small cyclic neuropeptide hormone oxytocin (OT) and its cognate receptor play a central role in the regulation of social behaviour and sexual reproduction. Here we report the single-particle cryo-electron microscopy structure of the active oxytocin receptor (OTR) in complex with its cognate ligand oxytocin. Our structure provides high-resolution insights into the OT binding mode, the OTR activation mechanism as well as the subtype specificity within the oxytocin/vasopressin receptor family.

Date: 2022
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DOI: 10.1038/s41467-022-31325-0

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