Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age

Birgit Burkhardt (), Ulf Michgehl, Jonas Rohde, Tabea Erdmann, Philipp Berning, Katrin Reutter, Marius Rohde, Arndt Borkhardt, Thomas Burmeister, Sandeep Dave, Alexandar Tzankov, Martin Dugas, Sarah Sandmann, Falko Fend, Jasmin Finger, Stephanie Mueller, Nicola Gökbuget, Torsten Haferlach, Wolfgang Kern, Wolfgang Hartmann, Wolfram Klapper, Ilske Oschlies, Julia Richter, Udo Kontny, Mathias Lutz, Britta Maecker-Kolhoff, German Ott, Andreas Rosenwald, Reiner Siebert, Arend Stackelberg, Brigitte Strahm, Wilhelm Woessmann, Martin Zimmermann, Myroslav Zapukhlyak, Michael Grau and Georg Lenz
Additional contact information
Birgit Burkhardt: University Hospital Münster
Ulf Michgehl: University Hospital Münster
Jonas Rohde: University Hospital Münster
Tabea Erdmann: University Hospital Münster
Philipp Berning: University Hospital Münster
Katrin Reutter: University Hospital Münster
Marius Rohde: University Hospital Giessen
Arndt Borkhardt: Heinrich-Heine-University
Thomas Burmeister: corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
Sandeep Dave: Duke University
Alexandar Tzankov: University Hospital Basel
Martin Dugas: Heidelberg University Hospital
Sarah Sandmann: University of Münster
Falko Fend: University Hospital Tübingen, Eberhard-Karls-University
Jasmin Finger: University Hospital Münster
Stephanie Mueller: University Hospital Münster
Nicola Gökbuget: Goethe University
Torsten Haferlach: MLL Munich Leukemia Laboratory
Wolfgang Kern: MLL Munich Leukemia Laboratory
Wolfgang Hartmann: University Hospital of Münster
Wolfram Klapper: University Hospital Schleswig-Holstein
Ilske Oschlies: University Hospital Schleswig-Holstein
Julia Richter: University Hospital Schleswig-Holstein
Udo Kontny: Department of Pediatric and Adolescent Medicine, RWTH Aachen University Hospital
Mathias Lutz: University of Augsburg
Britta Maecker-Kolhoff: Department of Pediatric Hematology and Oncology
German Ott: Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
Andreas Rosenwald: Universität Würzburg and Comprehensive Cancer Centre Mainfranken (CCCMF)
Reiner Siebert: Ulm University and Ulm University Medical Center
Arend Stackelberg: Charité - Universitätsmedizin Berlin
Brigitte Strahm: University of Freiburg
Wilhelm Woessmann: University Medical Centre Hamburg-Eppendorf
Martin Zimmermann: Department of Pediatric Hematology and Oncology
Myroslav Zapukhlyak: University Hospital Münster
Michael Grau: University Hospital Münster
Georg Lenz: University Hospital Münster

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract While survival has improved for Burkitt lymphoma patients, potential differences in outcome between pediatric and adult patients remain unclear. In both age groups, survival remains poor at relapse. Therefore, we conducted a comparative study in a large pediatric cohort, including 191 cases and 97 samples from adults. While TP53 and CCND3 mutation frequencies are not age related, samples from pediatric patients showed a higher frequency of mutations in ID3, DDX3X, ARID1A and SMARCA4, while several genes such as BCL2 and YY1AP1 are almost exclusively mutated in adult patients. An unbiased analysis reveals a transition of the mutational profile between 25 and 40 years of age. Survival analysis in the pediatric cohort confirms that TP53 mutations are significantly associated with higher incidence of relapse (25 ± 4% versus 6 ± 2%, p-value 0.0002). This identifies a promising molecular marker for relapse incidence in pediatric BL which will be used in future clinical trials.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31355-8

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DOI: 10.1038/s41467-022-31355-8

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