Deep learning to diagnose Hashimoto’s thyroiditis from sonographic images

Qiang Zhang, Sheng Zhang, Yi Pan, Lin Sun, Jianxin Li, Yu Qiao, Jing Zhao, Xiaoqing Wang, Yixing Feng, Yanhui Zhao, Zhiming Zheng, Xiangming Yang, Lixia Liu, Chunxin Qin, Ke Zhao, Xiaonan Liu, Caixia Li, Liuyang Zhang, Chunrui Yang, Na Zhuo, Hong Zhang, Jie Liu, Jinglei Gao, Xiaoling Di, Fanbo Meng, Linlei Zhang, Yuxuan Wang, Yuansheng Duan, Hongru Shen, Yang Li, Meng Yang, Yichen Yang, Xiaojie Xin, Xi Wei, Xuan Zhou, Rui Jin, Lun Zhang, Xudong Wang, Fengju Song, Xiangqian Zheng, Ming Gao, Kexin Chen () and Xiangchun Li ()
Additional contact information
Qiang Zhang: Tianjin Medical University
Sheng Zhang: Tianjin Medical University
Yi Pan: Tianjin Medical University
Lin Sun: Tianjin Medical University
Jianxin Li: Cheeloo College of Medicine
Yu Qiao: Tianjin Medical University
Jing Zhao: Tianjin Medical University
Xiaoqing Wang: Tianjin Medical University
Yixing Feng: Tianjin Medical University
Yanhui Zhao: Affiliated Hospital of Chifeng University
Zhiming Zheng: Integrated Traditional Chinese and Western Medicine Hospital of Jilin City Jilin Province
Xiangming Yang: Dezhou Municipal Hospital
Lixia Liu: Affiliated Hospital of Hebei University
Chunxin Qin: Weihai Municipal Hospital, Cheeloo College of Medicine
Ke Zhao: Tianjin Medical University General Hospital
Xiaonan Liu: Tianjin 4th Centre Hospital
Caixia Li: Tianjin 4th Centre Hospital
Liuyang Zhang: Affiliated Hospital of Chengde Medical University
Chunrui Yang: The Second Hospital of Tianjin Medical University
Na Zhuo: The Second Hospital of Tianjin Medical University
Hong Zhang: The Second Hospital of Jilin University
Jie Liu: Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine of Hebei Province
Jinglei Gao: People’s Hospital of Dingzhou
Xiaoling Di: People’s Hospital of Dingzhou
Fanbo Meng: Affiliated Hospital of Shaoxing University
Linlei Zhang: The Second Hospital of Hebei Medical University
Yuxuan Wang: Tianjin Medical University
Yuansheng Duan: Tianjin Medical University
Hongru Shen: Tianjin Medical University
Yang Li: Tianjin Medical University
Meng Yang: Tianjin Medical University
Yichen Yang: Tianjin Medical University
Xiaojie Xin: Tianjin Medical University
Xi Wei: Tianjin Medical University
Xuan Zhou: Tianjin Medical University
Rui Jin: Tianjin Medical University
Lun Zhang: Tianjin Medical University
Xudong Wang: Tianjin Medical University
Fengju Song: Tianjin Medical University
Xiangqian Zheng: Tianjin Medical University
Ming Gao: Tianjin Medical University
Kexin Chen: Tianjin Medical University
Xiangchun Li: Tianjin Medical University

Nature Communications, 2022, vol. 13, issue 1, 1-8

Abstract: Abstract Hashimoto’s thyroiditis (HT) is the main cause of hypothyroidism. We develop a deep learning model called HTNet for diagnosis of HT by training on 106,513 thyroid ultrasound images from 17,934 patients and test its performance on 5051 patients from 2 datasets of static images and 1 dataset of video data. HTNet achieves an area under the receiver operating curve (AUC) of 0.905 (95% CI: 0.894 to 0.915), 0.888 (0.836–0.939) and 0.895 (0.862–0.927). HTNet exceeds radiologists’ performance on accuracy (83.2% versus 79.8%; binomial test, p

Date: 2022
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DOI: 10.1038/s41467-022-31449-3

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