Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents

Jaime S. Rosa Duque, Xiwei Wang, Daniel Leung, Samuel M. S. Cheng, Carolyn A. Cohen, Xiaofeng Mu, Asmaa Hachim, Yanmei Zhang, Sau Man Chan, Sara Chaothai, Kelvin K. H. Kwan, Karl C. K. Chan, John K. C. Li, Leo L. H. Luk, Leo C. H. Tsang, Wilfred H. S. Wong, Cheuk Hei Cheang, Timothy K. Hung, Jennifer H. Y. Lam, Gilbert T. Chua, Winnie W. Y. Tso, Patrick Ip, Masashi Mori, Niloufar Kavian, Wing Hang Leung, Sophie Valkenburg (), Malik Peiris (), Wenwei Tu () and Yu Lung Lau ()
Additional contact information
Jaime S. Rosa Duque: The University of Hong Kong
Xiwei Wang: The University of Hong Kong
Daniel Leung: The University of Hong Kong
Samuel M. S. Cheng: The University of Hong Kong
Carolyn A. Cohen: The University of Hong Kong
Xiaofeng Mu: The University of Hong Kong
Asmaa Hachim: The University of Hong Kong
Yanmei Zhang: The University of Hong Kong
Sau Man Chan: The University of Hong Kong
Sara Chaothai: The University of Hong Kong
Kelvin K. H. Kwan: The University of Hong Kong
Karl C. K. Chan: The University of Hong Kong
John K. C. Li: The University of Hong Kong
Leo L. H. Luk: The University of Hong Kong
Leo C. H. Tsang: The University of Hong Kong
Wilfred H. S. Wong: The University of Hong Kong
Cheuk Hei Cheang: The University of Hong Kong
Timothy K. Hung: The University of Hong Kong
Jennifer H. Y. Lam: The University of Hong Kong
Gilbert T. Chua: The University of Hong Kong
Winnie W. Y. Tso: The University of Hong Kong
Patrick Ip: The University of Hong Kong
Masashi Mori: Ishikawa Prefectural University
Niloufar Kavian: The University of Hong Kong
Wing Hang Leung: The University of Hong Kong
Sophie Valkenburg: The University of Hong Kong
Malik Peiris: The University of Hong Kong
Wenwei Tu: The University of Hong Kong
Yu Lung Lau: The University of Hong Kong

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract We present an interim analysis of a registered clinical study (NCT04800133) to establish immunobridging with various antibody and cellular immunity markers and to compare the immunogenicity and reactogenicity of 2-dose BNT162b2 and CoronaVac in healthy adolescents as primary objectives. One-dose BNT162b2, recommended in some localities for risk reduction of myocarditis, is also assessed. Antibodies and T cell immune responses are non-inferior or similar in adolescents receiving 2 doses of BNT162b2 (BB, N = 116) and CoronaVac (CC, N = 123) versus adults after 2 doses of the same vaccine (BB, N = 147; CC, N = 141) but not in adolescents after 1-dose BNT162b2 (B, N = 116). CC induces SARS-CoV-2 N and N C-terminal domain seropositivity in a higher proportion of adolescents than adults. Adverse reactions are mostly mild for both vaccines and more frequent for BNT162b2. We find higher S, neutralising, avidity and Fc receptor-binding antibody responses in adolescents receiving BB than CC, and a similar induction of strong S-specific T cells by the 2 vaccines, in addition to N- and M-specific T cells induced by CoronaVac but not BNT162b2, possibly implying differential durability and cross-variant protection by BNT162b2 and CoronaVac, the 2 most used SARS-CoV-2 vaccines worldwide. Our results support the use of both vaccines in adolescents.

Date: 2022
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DOI: 10.1038/s41467-022-31485-z

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