Poor outcome of pediatric patients with acute myeloid leukemia harboring high FLT3/ITD allelic ratios

Kun-yin Qiu, Xiong-yu Liao, Yong Liu, Ke Huang, Yang Li, Jian-pei Fang () and Dun-hua Zhou ()
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Kun-yin Qiu: Sun Yat-sen University
Xiong-yu Liao: Sun Yat-sen University
Yong Liu: Sun Yat-sen University
Ke Huang: Sun Yat-sen University
Yang Li: Sun Yat-sen University
Jian-pei Fang: Sun Yat-sen University
Dun-hua Zhou: Sun Yat-sen University

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract Activating FLT3 mutations are the most common mutations in acute myeloid leukemia (AML), but the optimal threshold of FLT3/ITD allelic ratio (AR) among pediatric AML patients remains controversial. Here, we present the outcome and prognostic significance of FLT3/ITD AR analysis among pediatric patients with AML from the TARGET dataset. Applying fitting curve models and threshold effect analysis using the restrictive cubic spline function following Cox proportional hazards models identifies the cut-off value of 0.5 on FLT3/ITD AR. Moreover, we observe that high FLT3/ITD AR patients have an inferior outcome when compared to low AR patients. Our study also demonstrates that stem cell transplantation may improve the outcome in pediatric AML patients with high FLT3/ITD AR and may be further improved when combined with additional therapies such as Gemtuzumab Ozogamicin. These findings underline the importance of individualized treatment of pediatric AML.

Date: 2022
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DOI: 10.1038/s41467-022-31489-9

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