Effect of vaccination on household transmission of SARS-CoV-2 Delta variant of concern

Frederik Plesner Lyngse (), Kåre Mølbak, Matt Denwood, Lasse Engbo Christiansen, Camilla Holten Møller, Morten Rasmussen, Arieh Sierra Cohen, Marc Stegger, Jannik Fonager, Raphael Niklaus Sieber, Kirsten Maren Ellegaard, Claus Nielsen and Carsten Thure Kirkeby
Additional contact information
Frederik Plesner Lyngse: University of Copenhagen
Kåre Mølbak: Statens Serum Institut
Matt Denwood: University of Copenhagen
Lasse Engbo Christiansen: Technical University of Denmark
Camilla Holten Møller: Statens Serum Institut
Morten Rasmussen: Statens Serum Institut
Arieh Sierra Cohen: Statens Serum Institut
Marc Stegger: Statens Serum Institut
Jannik Fonager: Statens Serum Institut
Raphael Niklaus Sieber: Statens Serum Institut
Kirsten Maren Ellegaard: Statens Serum Institut
Claus Nielsen: Statens Serum Institut
Carsten Thure Kirkeby: University of Copenhagen

Nature Communications, 2022, vol. 13, issue 1, 1-8

Abstract: Abstract Effective vaccines protect individuals by not only reducing the susceptibility to infection, but also reducing the infectiousness of breakthrough infections in vaccinated cases. To disentangle the vaccine effectiveness against susceptibility to infection (VES) and vaccine effectiveness against infectiousness (VEI), we took advantage of Danish national data comprising 24,693 households with a primary case of SARS-CoV-2 infection (Delta Variant of Concern, 2021) including 53,584 household contacts. In this setting, we estimated VES as 61% (95%-CI: 59-63), when the primary case was unvaccinated, and VEI as 31% (95%-CI: 26-36), when the household contact was unvaccinated. Furthermore, unvaccinated secondary cases with an infection exhibited a three-fold higher viral load compared to fully vaccinated secondary cases with a breakthrough infection. Our results demonstrate that vaccinations reduce susceptibility to infection as well as infectiousness, which should be considered by policy makers when seeking to understand the public health impact of vaccination against transmission of SARS-CoV-2.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-022-31494-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31494-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-31494-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().