The megabase-scale crossover landscape is largely independent of sequence divergence

Qichao Lian, Victor Solier, Birgit Walkemeier, Stéphanie Durand, Bruno Huettel, Korbinian Schneeberger () and Raphael Mercier ()
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Qichao Lian: Max Planck Institute for Plant Breeding Research
Victor Solier: Max Planck Institute for Plant Breeding Research
Birgit Walkemeier: Max Planck Institute for Plant Breeding Research
Stéphanie Durand: Max Planck Institute for Plant Breeding Research
Bruno Huettel: Max Planck Institute for Plant Breeding Research
Korbinian Schneeberger: Max Planck Institute for Plant Breeding Research
Raphael Mercier: Max Planck Institute for Plant Breeding Research

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Meiotic recombination frequency varies along chromosomes and strongly correlates with sequence divergence. However, the causal relationship between recombination landscapes and polymorphisms is unclear. Here, we characterize the genome-wide recombination landscape in the quasi-absence of polymorphisms, using Arabidopsis thaliana homozygous inbred lines in which a few hundred genetic markers were introduced through mutagenesis. We find that megabase-scale recombination landscapes in inbred lines are strikingly similar to the recombination landscapes in hybrids, with the notable exception of heterozygous large rearrangements where recombination is prevented locally. In addition, the megabase-scale recombination landscape can be largely explained by chromatin features. Our results show that polymorphisms are not a major determinant of the shape of the megabase-scale recombination landscape but rather favour alternative models in which recombination and chromatin shape sequence divergence across the genome.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31509-8

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DOI: 10.1038/s41467-022-31509-8

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