Adenine oligomer directed synthesis of chiral gold nanoparticles

Nam Heon Cho, Young Bi Kim, Yoon Young Lee, Sang Won Im, Ryeong Myeong Kim, Jeong Won Kim, Seok Daniel Namgung, Hye-Eun Lee, Hyeohn Kim, Jeong Hyun Han, Hye Won Chung, Yoon Ho Lee, Jeong Woo Han () and Ki Tae Nam ()
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Nam Heon Cho: Seoul National University
Young Bi Kim: Pohang University of Science and Technology (POSTECH)
Yoon Young Lee: Seoul National University
Sang Won Im: Seoul National University
Ryeong Myeong Kim: Seoul National University
Jeong Won Kim: Seoul National University
Seok Daniel Namgung: Seoul National University
Hye-Eun Lee: Seoul National University
Hyeohn Kim: Seoul National University
Jeong Hyun Han: Seoul National University
Hye Won Chung: Seoul National University
Yoon Ho Lee: Seoul National University
Jeong Woo Han: Pohang University of Science and Technology (POSTECH)
Ki Tae Nam: Seoul National University

Nature Communications, 2022, vol. 13, issue 1, 1-10

Abstract: Abstract Precise control of morphology and optical response of 3-dimensional chiral nanoparticles remain as a significant challenge. This work demonstrates chiral gold nanoparticle synthesis using single-stranded oligonucleotide as a chiral shape modifier. The homo-oligonucleotide composed of Adenine nucleobase specifically show a distinct chirality development with a dissymmetric factor up to g ~ 0.04 at visible wavelength, whereas other nucleobases show no development of chirality. The synthesized nanoparticle shows a counter-clockwise rotation of generated chiral arms with approximately 200 nm edge length. The molecular dynamics and density functional theory simulations reveal that Adenine shows the highest enantioselective interaction with Au(321)R/S facet in terms of binding orientation and affinity. This is attributed to the formation of sequence-specific intra-strand hydrogen bonding between nucleobases. We also found that different sequence programming of Adenine-and Cytosine-based oligomers result in chiral gold nanoparticles’ morphological and optical change. These results extend our understanding of the biomolecule-directed synthesis of chiral gold nanoparticles to sequence programmable deoxyribonucleic acid and provides a foundation for programmable synthesis of chiral gold nanoparticles.

Date: 2022
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DOI: 10.1038/s41467-022-31513-y

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