A comprehensive resource for Bordetella genomic epidemiology and biodiversity studies

Sébastien Bridel, Valérie Bouchez, Bryan Brancotte, Sofia Hauck, Nathalie Armatys, Annie Landier, Estelle Mühle, Sophie Guillot, Julie Toubiana, Martin C. J. Maiden, Keith A. Jolley and Sylvain Brisse ()
Additional contact information
Sébastien Bridel: Biodiversity and Epidemiology of Bacterial Pathogens
Valérie Bouchez: Biodiversity and Epidemiology of Bacterial Pathogens
Bryan Brancotte: Bioinformatics and Biostatistics Hub
Sofia Hauck: University of Oxford
Nathalie Armatys: Biodiversity and Epidemiology of Bacterial Pathogens
Annie Landier: Biodiversity and Epidemiology of Bacterial Pathogens
Estelle Mühle: Université Paris Cité
Sophie Guillot: Biodiversity and Epidemiology of Bacterial Pathogens
Julie Toubiana: Biodiversity and Epidemiology of Bacterial Pathogens
Martin C. J. Maiden: University of Oxford
Keith A. Jolley: University of Oxford
Sylvain Brisse: Biodiversity and Epidemiology of Bacterial Pathogens

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract The genus Bordetella includes bacteria that are found in the environment and/or associated with humans and other animals. A few closely related species, including Bordetella pertussis, are human pathogens that cause diseases such as whooping cough. Here, we present a large database of Bordetella isolates and genomes and develop genotyping systems for the genus and for the B. pertussis clade. To generate the database, we merge previously existing databases from Oxford University and Institut Pasteur, import genomes from public repositories, and add 83 newly sequenced B. bronchiseptica genomes. The public database currently includes 2582 Bordetella isolates and their provenance data, and 2085 genomes ( https://bigsdb.pasteur.fr/bordetella/ ). We use core-genome multilocus sequence typing (cgMLST) to develop genotyping systems for the whole genus and for B. pertussis, as well as specific schemes to define antigenic, virulence and macrolide resistance profiles. Phylogenetic analyses allow us to redefine evolutionary relationships among known Bordetella species, and to propose potential new species. Our database provides an expandable resource for genotyping of environmental and clinical Bordetella isolates, thus facilitating evolutionary and epidemiological research on whooping cough and other Bordetella infections.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31517-8

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DOI: 10.1038/s41467-022-31517-8

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