Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis

Elle Koren, Alona Feldman, Marianna Yusupova, Avihay Kadosh, Egor Sedov, Roi Ankawa, Yahav Yosefzon, Waseem Nasser, Stefanie Gerstberger, Liam B. Kimel, Noa Priselac, Samara Brown, Sam Sharma, Travis Gorenc, Ruby Shalom-Feuerstein, Hermann Steller, Tom Shemesh () and Yaron Fuchs ()
Additional contact information
Elle Koren: Technion Israel Institute of Technology
Alona Feldman: Technion Israel Institute of Technology
Marianna Yusupova: Technion Israel Institute of Technology
Avihay Kadosh: Technion Israel Institute of Technology
Egor Sedov: Technion Israel Institute of Technology
Roi Ankawa: Technion Israel Institute of Technology
Yahav Yosefzon: Technion Israel Institute of Technology
Waseem Nasser: The Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology
Stefanie Gerstberger: Massachusetts General Hospital
Liam B. Kimel: Technion Israel Institute of Technology
Noa Priselac: Technion Israel Institute of Technology
Samara Brown: The Rockefeller University, New York
Sam Sharma: The Rockefeller University, New York
Travis Gorenc: The Rockefeller University, New York
Ruby Shalom-Feuerstein: The Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology
Hermann Steller: The Rockefeller University, New York
Tom Shemesh: Technion Israel Institute of Technology
Yaron Fuchs: Technion Israel Institute of Technology

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract The presence of distinct stem cells that maintain the interfollicular epidermis is highly debated. Here, we report a population of keratinocytes, marked by Thy1, in the basal layer of the interfollicular epidermis. We find that epidermal cells expressing differential levels of Thy1 display distinct transcriptional signatures. Thy1+ keratinocytes do not express T cell markers, express a unique transcriptional profile, cycle significantly slower than basal epidermal progenitors and display significant expansion potential in vitro. Multicolor lineage tracing analyses and mathematical modeling reveal that Thy1+ basal keratinocytes do not compete neutrally alike interfollicular progenitors and contribute long-term to both epidermal replenishment and wound repair. Importantly, ablation of Thy1+ cells strongly impairs these processes, thus indicating the non-redundant function of Thy1+ stem cells in the epidermis. Collectively, these results reveal a distinct stem cell population that plays a critical role in epidermal homeostasis and repair.

Date: 2022
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DOI: 10.1038/s41467-022-31629-1

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