Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

Qi Song, Ye Yang, Dongxian Jiang, Zhaoyu Qin, Chen Xu, Haixing Wang, Jie Huang, Lingli Chen, Rongkui Luo, Xiaolei Zhang, Yufeng Huang, Lei Xu, Zixiang Yu, Subei Tan, Minying Deng, Ruqun Xue, Jingbo Qie, Kai Li, Yanan Yin, Xuetong Yue, Xiaogang Sun, Jieakesu Su, Fuchu He (), Chen Ding () and Yingyong Hou ()
Additional contact information
Qi Song: Fudan University
Ye Yang: Fudan University
Dongxian Jiang: Fudan University
Zhaoyu Qin: Fudan University
Chen Xu: Fudan University
Haixing Wang: Fudan University
Jie Huang: Fudan University
Lingli Chen: Fudan University
Rongkui Luo: Fudan University
Xiaolei Zhang: Fudan University
Yufeng Huang: Fudan University
Lei Xu: Fudan University
Zixiang Yu: Fudan University
Subei Tan: Fudan University
Minying Deng: Fudan University
Ruqun Xue: Fudan University
Jingbo Qie: Fudan University
Kai Li: Fudan University
Yanan Yin: Fudan University
Xuetong Yue: Fudan University
Xiaogang Sun: Henan Normal University
Jieakesu Su: Fudan University
Fuchu He: Beijing Institute of Lifeomics
Chen Ding: Fudan University
Yingyong Hou: Fudan University

Nature Communications, 2022, vol. 13, issue 1, 1-20

Abstract: Abstract Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are two main histological subtypes of solid cancer; however, SCCs are derived from different organs with similar morphologies, and it is challenging to distinguish the origin of metastatic SCCs. Here we report a deep proteomic analysis of 333 SCCs of 17 organs and 69 ACs of 7 organs. Proteomic comparison between SCCs and ACs identifies distinguishable pivotal pathways and molecules in those pathways play consistent adverse or opposite prognostic roles in ACs and SCCs. A comparison between common and rare SCCs highlights lipid metabolism may reinforce the malignancy of rare SCCs. Proteomic clusters reveal anatomical features, and kinase-transcription factor networks indicate differential SCC characteristics, while immune subtyping reveals diverse tumor microenvironments across and within diagnoses and identified potential druggable targets. Furthermore, tumor-specific proteins provide candidates with differentially diagnostic values. This proteomics architecture represents a public resource for researchers seeking a better understanding of SCCs and ACs.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31719-0

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DOI: 10.1038/s41467-022-31719-0

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