Dietary protein increases T-cell-independent sIgA production through changes in gut microbiota-derived extracellular vesicles

Jian Tan, Duan Ni, Jemma Taitz, Gabriela Veronica Pinget, Mark Read, Alistair Senior, Jibran Abdul Wali, Reem Elnour, Erin Shanahan, Huiling Wu, Steven J. Chadban, Ralph Nanan, Nicholas Jonathan Cole King, Georges Emile Grau, Stephen J. Simpson and Laurence Macia ()
Additional contact information
Jian Tan: The University of Sydney
Duan Ni: The University of Sydney
Jemma Taitz: The University of Sydney
Gabriela Veronica Pinget: The University of Sydney
Mark Read: The University of Sydney
Alistair Senior: The University of Sydney
Jibran Abdul Wali: The University of Sydney
Reem Elnour: The University of Sydney
Erin Shanahan: The University of Sydney
Huiling Wu: The University of Sydney
Steven J. Chadban: The University of Sydney
Ralph Nanan: The University of Sydney
Nicholas Jonathan Cole King: The University of Sydney
Georges Emile Grau: University of Sydney
Stephen J. Simpson: The University of Sydney
Laurence Macia: The University of Sydney

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Secretory IgA is a key mucosal component ensuring host-microbiota mutualism. Here we use nutritional geometry modelling in mice fed 10 different macronutrient-defined, isocaloric diets, and identify dietary protein as the major driver of secretory IgA production. Protein-driven secretory IgA induction is not mediated by T-cell-dependent pathways or changes in gut microbiota composition. Instead, the microbiota of high protein fed mice produces significantly higher quantities of extracellular vesicles, compared to those of mice fed high-carbohydrate or high-fat diets. These extracellular vesicles activate Toll-like receptor 4 to increase the epithelial expression of IgA-inducing cytokine, APRIL, B cell chemokine, CCL28, and the IgA transporter, PIGR. We show that succinate, produced in high concentrations by microbiota of high protein fed animals, increases generation of reactive oxygen species by bacteria, which in turn promotes extracellular vesicles production. Here we establish a link between dietary macronutrient composition, gut microbial extracellular vesicles release and host secretory IgA response.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-31761-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31761-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-31761-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().