A synaptic signal for novelty processing in the hippocampus

Ruy Gómez-Ocádiz, Massimiliano Trippa, Chun-Lei Zhang, Lorenzo Posani, Simona Cocco, Rémi Monasson and Christoph Schmidt-Hieber ()
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Ruy Gómez-Ocádiz: Université Paris Cité, Neural Circuits for Spatial Navigation and Memory, Department of Neuroscience
Massimiliano Trippa: Sorbonne Université, Université Paris Cité
Chun-Lei Zhang: Université Paris Cité, Neural Circuits for Spatial Navigation and Memory, Department of Neuroscience
Lorenzo Posani: Université Paris Cité, Neural Circuits for Spatial Navigation and Memory, Department of Neuroscience
Simona Cocco: Sorbonne Université, Université Paris Cité
Rémi Monasson: Sorbonne Université, Université Paris Cité
Christoph Schmidt-Hieber: Université Paris Cité, Neural Circuits for Spatial Navigation and Memory, Department of Neuroscience

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Episodic memory formation and recall are complementary processes that rely on opposing neuronal computations in the hippocampus. How this conflict is resolved in hippocampal circuits is unclear. To address this question, we obtained in vivo whole-cell patch-clamp recordings from dentate gyrus granule cells in head-fixed mice trained to explore and distinguish between familiar and novel virtual environments. We find that granule cells consistently show a small transient depolarisation upon transition to a novel environment. This synaptic novelty signal is sensitive to local application of atropine, indicating that it depends on metabotropic acetylcholine receptors. A computational model suggests that the synaptic response to novelty may bias granule cell population activity, which can drive downstream attractor networks to a new state, favouring the switch from recall to new memory formation when faced with novelty. Such a novelty-driven switch may enable flexible encoding of new memories while preserving stable retrieval of familiar ones.

Date: 2022
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DOI: 10.1038/s41467-022-31775-6

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