Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation

Haider Ghaidan, Martin Stenlo, Anna Niroomand, Margareta Mittendorfer, Gabriel Hirdman, Nika Gvazava, Dag Edström, Iran A. N. Silva, Ellen Broberg, Oskar Hallgren, Franziska Olm, Darcy E. Wagner, Leif Pierre, Snejana Hyllén and Sandra Lindstedt ()
Additional contact information
Haider Ghaidan: Skåne University Hospital
Martin Stenlo: Lund University
Anna Niroomand: Lund University
Margareta Mittendorfer: Lund University
Gabriel Hirdman: Lund University
Nika Gvazava: Lund University
Dag Edström: Lund University
Iran A. N. Silva: Lund University
Ellen Broberg: Lund University
Oskar Hallgren: Lund University
Franziska Olm: Skåne University Hospital
Darcy E. Wagner: Lund University
Leif Pierre: Skåne University Hospital
Snejana Hyllén: Lund University
Sandra Lindstedt: Skåne University Hospital

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Despite improvements, lung transplantation remains hampered by both a scarcity of donor organs and by mortality following primary graft dysfunction (PGD). Since acute respiratory distress syndrome (ARDS) limits donor lungs utilization, we investigated cytokine adsorption as a means of treating ARDS donor lungs. We induced mild to moderate ARDS using lipopolysaccharide in 16 donor pigs. Lungs were then treated with or without cytokine adsorption during ex vivo lung perfusion (EVLP) and/or post-transplantation using extracorporeal hemoperfusion. The treatment significantly decreased cytokine levels during EVLP and decreased levels of immune cells post-transplantation. Histology demonstrated fewer signs of lung injury across both treatment periods and the incidence of PGD was significantly reduced among treated animals. Overall, cytokine adsorption was able to restore lung function and reduce PGD in lung transplantation. We suggest this treatment will increase the availability of donor lungs and increase the tolerability of donor lungs in the recipient.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31811-5

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DOI: 10.1038/s41467-022-31811-5

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