Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study

Husam M. Salah, Marat Fudim (), Shawn T. O’Neil, Amin Manna, Christopher G. Chute and Melissa C. Caughey
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Husam M. Salah: University of Arkansas for Medical Sciences
Marat Fudim: Duke University School of Medicine
Shawn T. O’Neil: University of Colorado Anschutz Medical Campus
Amin Manna: Palantir Technologies
Christopher G. Chute: Johns Hopkins University
Melissa C. Caughey: University of North Carolina and North Carolina State University

Nature Communications, 2022, vol. 13, issue 1, 1-6

Abstract: Abstract Cardiac involvement has been noted in COVID-19 infection. However, the relationship between post-recovery COVID-19 and development of de novo heart failure has not been investigated in a large, nationally representative population. We examined post-recovery outcomes of 587,330 patients hospitalized in the United States (257,075 with COVID-19 and 330,255 without), using data from the National COVID Cohort Collaborative study. Patients hospitalized with COVID-19 were older (51 vs. 46 years), more often male (49% vs. 42%), and less often White (61% vs. 69%). Over a median follow up of 367 days, 10,979 incident heart failure events occurred. After adjustments, COVID-19 hospitalization was associated with a 45% higher hazard of incident heart failure (hazard ratio = 1.45; 95% confidence interval: 1.39–1.51), with more pronounced associations among patients who were younger (P-interaction = 0.003), White (P-interaction = 0.005), or who had established cardiovascular disease (P-interaction = 0.005). In conclusion, COVID-19 hospitalization is associated with increased risk of incident heart failure.

Date: 2022
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DOI: 10.1038/s41467-022-31834-y

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