Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection

T. Ferry (), C. Kolenda, F. Laurent, G. Leboucher, M. Merabischvilli, S. Djebara, C.-A. Gustave, T. Perpoint, C. Barrey, J.-P. Pirnay and G. Resch
Additional contact information
T. Ferry: Hôpital de la Croix-rousse, Hospices Civils de Lyon
C. Kolenda: Université Claude Bernard Lyon 1
F. Laurent: Université Claude Bernard Lyon 1
G. Leboucher: Hôpital de la Croix-rousse, Hospices Civils de Lyon
M. Merabischvilli: Queen Astrid Military Hospital
S. Djebara: Queen Astrid Military Hospital
C.-A. Gustave: Université Claude Bernard Lyon 1
T. Perpoint: Hôpital de la Croix-rousse, Hospices Civils de Lyon
C. Barrey: Hôpital Pierre Wertheimer, Hospices Civils de Lyon
J.-P. Pirnay: Queen Astrid Military Hospital
G. Resch: Lausanne University Hospital

Nature Communications, 2022, vol. 13, issue 1, 1-6

Abstract: Abstract Bone and joint infections (BJI) are one of the most difficult-to-treat bacterial infection, especially in the era of antimicrobial resistance. Lytic bacteriophages (phages for short) are natural viruses that can selectively target and kill bacteria. They are considered to have a high therapeutic potential for the treatment of severe bacterial infections and especially BJI, as they also target biofilms. Here we report on the management of a patient with a pandrug-resistant Pseudomonas aeruginosa spinal abscess who was treated with surgery and a personalized combination of phage therapy that was added to antibiotics. As the infecting P. aeruginosa strain was resistant to the phages developed by private companies that were contacted, we set up a unique European academic collaboration to find, produce and administer a personalized phage cocktail to the patient in due time. After two surgeries, despite bacterial persistence with expression of small colony variants, the patient healed with local and intravenous injections of purified phages as adjuvant therapy.

Date: 2022
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DOI: 10.1038/s41467-022-31837-9

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