Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion

Chrispin Chaguza (), Dorota Jamrozy, Merijn W. Bijlsma, Taco W. Kuijpers, Diederik Beek, Arie Ende () and Stephen D. Bentley ()
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Chrispin Chaguza: Wellcome Genome Campus
Dorota Jamrozy: Wellcome Genome Campus
Merijn W. Bijlsma: Amsterdam University Medical Center, University of Amsterdam
Taco W. Kuijpers: University of Amsterdam
Diederik Beek: Amsterdam University Medical Center, University of Amsterdam
Arie Ende: Amsterdam University Medical Center, University of Amsterdam
Stephen D. Bentley: Wellcome Genome Campus

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract Group B Streptococcus (GBS), or Streptococcus agalactiae, is a pathogen that causes preterm births, stillbirths, and acute invasive neonatal disease burden and mortality. Here, we investigate bacterial genetic signatures associated with disease onset time and meningeal tissue infection in acute invasive neonatal GBS disease. We carry out a genome-wide association study (GWAS) of 1,338 GBS isolates from newborns with acute invasive disease; the isolates had been collected annually, for 30 years, through a national bacterial surveillance program in the Netherlands. After controlling for the population structure, we identify genetic variation within noncoding and coding regions, particularly the capsule biosynthesis locus, statistically associated with neonatal GBS disease onset time and meningeal invasion. Our findings highlight the impact of integrating microbial population genomics and clinical pathogen surveillance, and demonstrate the effect of GBS genetics on disease pathogenesis in neonates and infants.

Date: 2022
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DOI: 10.1038/s41467-022-31858-4

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