Shared mechanisms across the major psychiatric and neurodegenerative diseases

Thomas S. Wingo (), Yue Liu, Ekaterina S. Gerasimov, Selina M. Vattathil, Meghan E. Wynne, Jiaqi Liu, Adriana Lori, Victor Faundez, David A. Bennett, Nicholas T. Seyfried, Allan I. Levey and Aliza P. Wingo ()
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Thomas S. Wingo: Emory University School of Medicine
Yue Liu: Emory University School of Medicine
Ekaterina S. Gerasimov: Emory University School of Medicine
Selina M. Vattathil: Emory University School of Medicine
Meghan E. Wynne: Emory University School of Medicine
Jiaqi Liu: Emory University School of Medicine
Adriana Lori: Emory University School of Medicine
Victor Faundez: Emory University School of Medicine
David A. Bennett: Rush University Medical Center
Nicholas T. Seyfried: Emory University School of Medicine
Allan I. Levey: Emory University School of Medicine
Aliza P. Wingo: Emory University School of Medicine

Nature Communications, 2022, vol. 13, issue 1, 1-19

Abstract: Abstract Several common psychiatric and neurodegenerative diseases share epidemiologic risk; however, whether they share pathophysiology is unclear and is the focus of our investigation. Using 25 GWAS results and LD score regression, we find eight significant genetic correlations between psychiatric and neurodegenerative diseases. We integrate the GWAS results with human brain transcriptomes (n = 888) and proteomes (n = 722) to identify cis- and trans- transcripts and proteins that are consistent with a pleiotropic or causal role in each disease, referred to as causal proteins for brevity. Within each disease group, we find many distinct and shared causal proteins. Remarkably, 30% (13 of 42) of the neurodegenerative disease causal proteins are shared with psychiatric disorders. Furthermore, we find 2.6-fold more protein-protein interactions among the psychiatric and neurodegenerative causal proteins than expected by chance. Together, our findings suggest these psychiatric and neurodegenerative diseases have shared genetic and molecular pathophysiology, which has important ramifications for early treatment and therapeutic development.

Date: 2022
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DOI: 10.1038/s41467-022-31873-5

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