Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation

Mingyang Li, Xinyang Jin, Tao Liu, Feng Fan, Feng Gao, Shuang Chai and Lihua Yang ()
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Mingyang Li: University of Science and Technology of China
Xinyang Jin: University of Science and Technology of China
Tao Liu: University of Science and Technology of China
Feng Fan: University of Science and Technology of China
Feng Gao: University of Science and Technology of China
Shuang Chai: University of Science and Technology of China
Lihua Yang: University of Science and Technology of China

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Nanoparticle elasticity is crucial in nanoparticles’ physiological fate, but how this occurs is largely unknown. Using core-shell nanoparticles with a same PEGylated lipid bilayer shell yet cores differing in elasticity (45 kPa – 760 MPa) as models, we isolate the effects of nanoparticle elasticity from those of other physiochemical parameters and, using mouse models, observe a non-monotonic relationship of systemic circulation lifetime versus nanoparticle elasticity. Incubating our nanoparticles in mouse plasma provides protein coronas varying non-monotonically in composition depending on nanoparticle elasticity. Particularly, apolipoprotein A-I (ApoA1) is the only protein whose relative abundance in corona strongly correlates with our nanoparticles’ blood clearance lifetime. Notably, similar results are observed when above nanoparticles’ PEGylated lipid bilayer shell is changed to be non-PEGylated. This work unveils the mechanisms by which nanoparticle elasticity affects nanoparticles’ physiological fate and suggests nanoparticle elasticity as a readily tunable parameter in future rational exploiting of protein corona.

Date: 2022
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DOI: 10.1038/s41467-022-31882-4

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