Development of a novel core genome MLST scheme for tracing multidrug resistant Staphylococcus capitis

Zhengan Wang, Chao Gu, Lu Sun, Feng Zhao, Ying Fu, Lingfang Di, Junxiong Zhang, Hemu Zhuang, Shengnan Jiang, Haiping Wang, Feiteng Zhu, Yiyi Chen, Mengzhen Chen, Xia Ling, Yan Chen () and Yunsong Yu ()
Additional contact information
Zhengan Wang: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Chao Gu: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Lu Sun: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Feng Zhao: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Ying Fu: Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
Lingfang Di: Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
Junxiong Zhang: Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
Hemu Zhuang: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Shengnan Jiang: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Haiping Wang: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Feiteng Zhu: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Yiyi Chen: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Mengzhen Chen: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Xia Ling: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Yan Chen: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Yunsong Yu: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

Nature Communications, 2022, vol. 13, issue 1, 1-8

Abstract: Abstract Staphylococcus capitis, which causes bloodstream infections in neonatal intensive care units, is a common cause of healthcare-associated infections. Thus, a standardized high-resolution typing method to document the transmission and dissemination of multidrug-resistant S. capitis isolates is required. We aimed to establish a core genome multilocus sequence typing (cgMLST) scheme to surveil S. capitis. The cgMLST scheme was defined based on primary and validation genome sets and tested with outbreaks of linezolid-resistant isolates and a validation set. Phylogenetic analysis was performed to investigate the population structure and compare it with the result of cgMLST analysis. The S. capitis population consists of 1 dominant, NRCS-A, and 4 less common clones. In this work, a multidrug-resistant clone (L clone) with linezolid resistance is identified. With the features of type III SCCmec and multiple copies of mutations of G2576T and C2104T in the 23S rRNA, the L clone has been spreading silently across China.

Date: 2022
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DOI: 10.1038/s41467-022-31908-x

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