A temperature-regulated circuit for feeding behavior

Shaowen Qian (), Sumei Yan, Ruiqi Pang, Jing Zhang, Kai Liu, Zhiyue Shi, Zhaoqun Wang, Penghui Chen, Yanjie Zhang, Tiantian Luo, Xianli Hu, Ying Xiong () and Yi Zhou ()
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Shaowen Qian: Army Medical University
Sumei Yan: Army Medical University
Ruiqi Pang: Army Medical University
Jing Zhang: National Clinical Research Center for Cancer
Kai Liu: The 960th Hospital of Joint Logistics Support Force of PLA (Former Jinan Military General Hospital)
Zhiyue Shi: Army Medical University
Zhaoqun Wang: Army Medical University
Penghui Chen: Army Medical University
Yanjie Zhang: Army Medical University
Tiantian Luo: Army Medical University
Xianli Hu: Army Medical University
Ying Xiong: Army Medical University
Yi Zhou: Army Medical University

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract Both rodents and primates have evolved to orchestrate food intake to maintain thermal homeostasis in coping with ambient temperature challenges. However, the mechanisms underlying temperature-coordinated feeding behavior are rarely reported. Here we find that a non-canonical feeding center, the anteroventral and periventricular portions of medial preoptic area (apMPOA) respond to altered dietary states in mice. Two neighboring but distinct neuronal populations in apMPOA mediate feeding behavior by receiving anatomical inputs from external and dorsal subnuclei of lateral parabrachial nucleus. While both populations are glutamatergic, the arcuate nucleus-projecting neurons in apMPOA can sense low temperature and promote food intake. The other type, the paraventricular hypothalamic nucleus (PVH)-projecting neurons in apMPOA are primarily sensitive to high temperature and suppress food intake. Caspase ablation or chemogenetic inhibition of the apMPOA→PVH pathway can eliminate the temperature dependence of feeding. Further projection-specific RNA sequencing and fluorescence in situ hybridization identify that the two neuronal populations are molecularly marked by galanin receptor and apelin receptor. These findings reveal unrecognized cell populations and circuits of apMPOA that orchestrates feeding behavior against thermal challenges.

Date: 2022
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DOI: 10.1038/s41467-022-31917-w

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