Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

Li Wang, Markus H. Kainulainen, Nannan Jiang, Han Di, Gaston Bonenfant, Lisa Mills, Michael Currier, Punya Shrivastava-Ranjan, Brenda M. Calderon, Mili Sheth, Brian R. Mann, Jaber Hossain, Xudong Lin, Sandra Lester, Elizabeth A. Pusch, Joyce Jones, Dan Cui, Payel Chatterjee, M. Harley Jenks, Esther K. Morantz, Gloria P. Larson, Masato Hatta, Jennifer L. Harcourt, Azaibi Tamin, Yan Li, Ying Tao, Kun Zhao, Kristine Lacek, Ashley Burroughs, Wei Wang, Malania Wilson, Terianne Wong, So Hee Park, Suxiang Tong, John R. Barnes, Mark W. Tenforde, Wesley H. Self, Nathan I. Shapiro, Matthew C. Exline, D. Clark Files, Kevin W. Gibbs, David N. Hager, Manish Patel, Alison L. Halpin, Laura K. McMullan, Justin S. Lee, Hongjie Xia, Xuping Xie, Pei-Yong Shi, C. Todd Davis, Christina F. Spiropoulou, Natalie J. Thornburg, M. Steven Oberste, Vivien G. Dugan, David E. Wentworth () and Bin Zhou ()
Additional contact information
Li Wang: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Markus H. Kainulainen: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Nannan Jiang: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Han Di: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Gaston Bonenfant: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Lisa Mills: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Michael Currier: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Punya Shrivastava-Ranjan: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Brenda M. Calderon: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Mili Sheth: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Brian R. Mann: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Jaber Hossain: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Xudong Lin: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Sandra Lester: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Elizabeth A. Pusch: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Joyce Jones: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Dan Cui: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Payel Chatterjee: COVID-19 Emergency Response, Centers for Disease Control and Prevention
M. Harley Jenks: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Esther K. Morantz: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Gloria P. Larson: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Masato Hatta: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Jennifer L. Harcourt: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Azaibi Tamin: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Yan Li: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Ying Tao: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Kun Zhao: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Kristine Lacek: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Ashley Burroughs: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Wei Wang: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Malania Wilson: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Terianne Wong: COVID-19 Emergency Response, Centers for Disease Control and Prevention
So Hee Park: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Suxiang Tong: COVID-19 Emergency Response, Centers for Disease Control and Prevention
John R. Barnes: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Mark W. Tenforde: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Wesley H. Self: Vanderbilt University
Nathan I. Shapiro: Harvard University
Matthew C. Exline: Ohio State University
D. Clark Files: Wake Forest Baptist Medical Center
Kevin W. Gibbs: Wake Forest Baptist Medical Center
David N. Hager: Johns Hopkins University
Manish Patel: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Alison L. Halpin: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Laura K. McMullan: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Justin S. Lee: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Hongjie Xia: University of Texas Medical Branch
Xuping Xie: University of Texas Medical Branch
Pei-Yong Shi: University of Texas Medical Branch
C. Todd Davis: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Christina F. Spiropoulou: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Natalie J. Thornburg: COVID-19 Emergency Response, Centers for Disease Control and Prevention
M. Steven Oberste: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Vivien G. Dugan: COVID-19 Emergency Response, Centers for Disease Control and Prevention
David E. Wentworth: COVID-19 Emergency Response, Centers for Disease Control and Prevention
Bin Zhou: COVID-19 Emergency Response, Centers for Disease Control and Prevention

Nature Communications, 2022, vol. 13, issue 1, 1-10

Abstract: Abstract The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence of new variant lineages that have exacerbated the COVID-19 pandemic. Some of those variants were designated as variants of concern/interest (VOC/VOI) by national or international authorities based on many factors including their potential impact on vaccine-mediated protection from disease. To ascertain and rank the risk of VOCs and VOIs, we analyze the ability of 14 variants (614G, Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta, Iota, Kappa, Lambda, Mu, and Omicron) to escape from mRNA vaccine-induced antibodies. The variants show differential reductions in neutralization and replication by post-vaccination sera. Although the Omicron variant (BA.1, BA.1.1, and BA.2) shows the most escape from neutralization, sera collected after a third dose of vaccine (booster sera) retain moderate neutralizing activity against that variant. Therefore, vaccination remains an effective strategy during the COVID-19 pandemic.

Date: 2022
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DOI: 10.1038/s41467-022-31929-6

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