Cell landscape of larval and adult Xenopus laevis at single-cell resolution

Yuan Liao, Lifeng Ma, Qile Guo, Weigao E, Xing Fang, Lei Yang, Fanwei Ruan, Jingjing Wang, Peijing Zhang, Zhongyi Sun, Haide Chen, Zhongliang Lin, Xueyi Wang, Xinru Wang, Huiyu Sun, Xiunan Fang, Yincong Zhou, Ming Chen, Wanhua Shen (), Guoji Guo () and Xiaoping Han ()
Additional contact information
Yuan Liao: Zhejiang University School of Medicine
Lifeng Ma: Zhejiang University School of Medicine
Qile Guo: Zhejiang University School of Medicine
Weigao E: Zhejiang University School of Medicine
Xing Fang: Zhejiang University School of Medicine
Lei Yang: Zhejiang University School of Medicine
Fanwei Ruan: Zhejiang University School of Medicine
Jingjing Wang: Zhejiang University School of Medicine
Peijing Zhang: Zhejiang University School of Medicine
Zhongyi Sun: Zhejiang University School of Medicine
Haide Chen: Zhejiang University School of Medicine
Zhongliang Lin: Zhejiang University School of Medicine
Xueyi Wang: Zhejiang University School of Medicine
Xinru Wang: Zhejiang University School of Medicine
Huiyu Sun: Zhejiang University School of Medicine
Xiunan Fang: Zhejiang University Medical Center
Yincong Zhou: Zhejiang University
Ming Chen: Zhejiang University
Wanhua Shen: Hangzhou Normal University
Guoji Guo: Zhejiang University School of Medicine
Xiaoping Han: Zhejiang University School of Medicine

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract The rapid development of high-throughput single-cell RNA sequencing technology offers a good opportunity to dissect cell heterogeneity of animals. A large number of organism-wide single-cell atlases have been constructed for vertebrates such as Homo sapiens, Macaca fascicularis, Mus musculus and Danio rerio. However, an intermediate taxon that links mammals to vertebrates of more ancient origin is still lacking. Here, we construct the first Xenopus cell landscape to date, including larval and adult organs. Common cell lineage-specific transcription factors have been identified in vertebrates, including fish, amphibians and mammals. The comparison of larval and adult erythrocytes identifies stage-specific hemoglobin subtypes, as well as a common type of cluster containing both larval and adult hemoglobin, mainly at NF59. In addition, cell lineages originating from all three layers exhibits both antigen processing and presentation during metamorphosis, indicating a common regulatory mechanism during metamorphosis. Overall, our study provides a large-scale resource for research on Xenopus metamorphosis and adult organs.

Date: 2022
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DOI: 10.1038/s41467-022-31949-2

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