Single-cell transcriptome atlas of the human corpus cavernosum

LiangYu Zhao, Sha Han, HengChuan Su, JianYing Li, ErLei Zhi, Peng Li, ChenCheng Yao, RuHui Tian, HuiXing Chen, HuiRong Chen, JiaQiang Luo, ChenKun Shi, ZhiYong Ji, JianLin Hu, Gang Wu, WeiDong Zhou, YuXin Tang, YuZhuo Chen, GuiTing Lin, Tom F. Lue (), DengLong Wu () and Zheng Li ()
Additional contact information
LiangYu Zhao: Shanghai Jiao Tong University School of Medicine
Sha Han: Shanghai Jiao Tong University School of Medicine
HengChuan Su: Fudan University
JianYing Li: Shanghai Jiao Tong University School of Medicine
ErLei Zhi: Shanghai Jiao Tong University School of Medicine
Peng Li: Shanghai Jiao Tong University School of Medicine
ChenCheng Yao: Shanghai Jiao Tong University School of Medicine
RuHui Tian: Shanghai Jiao Tong University School of Medicine
HuiXing Chen: Shanghai Jiao Tong University School of Medicine
HuiRong Chen: Shanghai Jiao Tong University School of Medicine
JiaQiang Luo: Shanghai Jiao Tong University School of Medicine
ChenKun Shi: Shanghai Jiao Tong University School of Medicine
ZhiYong Ji: Shanghai Jiao Tong University School of Medicine
JianLin Hu: Shanghai Jiao Tong University School of Medicine
Gang Wu: Tongji University
WeiDong Zhou: Tongji University
YuXin Tang: Sun Yat-sen University
YuZhuo Chen: Sun Yat-sen University
GuiTing Lin: University of California
Tom F. Lue: University of California
DengLong Wu: Fudan University
Zheng Li: Shanghai Jiao Tong University School of Medicine

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract The corpus cavernosum is the most important structure for penile erection, and its dysfunction causes many physiological and psychological problems. However, its cellular heterogeneity and signalling networks at the molecular level are poorly understood because of limited access to samples. Here, we profile 64,993 human cavernosal single-cell transcriptomes from three males with normal erection and five organic erectile dysfunction patients. Cell communication analysis reveals that cavernosal fibroblasts are central to the paracrine signalling network and regulate microenvironmental homeostasis. Combining with immunohistochemical staining, we reveal the cellular heterogeneity and describe a detailed spatial distribution map for each fibroblast, smooth muscle and endothelial subcluster in the corpus cavernosum. Furthermore, comparative analysis and related functional experiments identify candidate regulatory signalling pathways in the pathological process. Our study provides an insight into the human corpus cavernosum microenvironment and a reference for potential erectile dysfunction therapies.

Date: 2022
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DOI: 10.1038/s41467-022-31950-9

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