A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans

Priya Jaitly, Mélanie Legrand, Abhijit Das, Tejas Patel, Murielle Chauvel, Corinne Maufrais, Christophe d’Enfert () and Kaustuv Sanyal ()
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Priya Jaitly: Jawaharlal Nehru Centre for Advanced Scientific Research
Mélanie Legrand: Université Paris Cité, INRAE, USC2019, Unité Biologie et Pathogénicité Fongiques
Abhijit Das: Jawaharlal Nehru Centre for Advanced Scientific Research
Tejas Patel: Jawaharlal Nehru Centre for Advanced Scientific Research
Murielle Chauvel: Université Paris Cité, INRAE, USC2019, Unité Biologie et Pathogénicité Fongiques
Corinne Maufrais: Université Paris Cité, Bioinformatics and Biostatistics Hub
Christophe d’Enfert: Université Paris Cité, INRAE, USC2019, Unité Biologie et Pathogénicité Fongiques
Kaustuv Sanyal: Jawaharlal Nehru Centre for Advanced Scientific Research

Nature Communications, 2022, vol. 13, issue 1, 1-18

Abstract: Abstract Chromosomal instability caused by cell division errors is associated with antifungal drug resistance in fungal pathogens. Here, we identify potential mechanisms underlying such instability by conducting an overexpression screen monitoring chromosomal stability in the human fungal pathogen Candida albicans. Analysis of ~1000 genes uncovers six chromosomal stability (CSA) genes, five of which are related to cell division genes of other organisms. The sixth gene, CSA6, appears to be present only in species belonging to the CUG-Ser clade, which includes C. albicans and other human fungal pathogens. The protein encoded by CSA6 localizes to the spindle pole bodies, is required for exit from mitosis, and induces a checkpoint-dependent metaphase arrest upon overexpression. Thus, Csa6 is an essential cell cycle progression factor that is restricted to the CUG-Ser fungal clade, and could therefore be explored as a potential antifungal target.

Date: 2022
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DOI: 10.1038/s41467-022-31980-3

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