UV photonic integrated circuits for far-field structured illumination autofluorescence microscopy

Chupao Lin (), Juan Santo Domingo Peñaranda, Jolien Dendooven, Christophe Detavernier, David Schaubroeck, Nico Boon, Roel Baets and Nicolas Le Thomas ()
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Chupao Lin: Ghent University-imec
Juan Santo Domingo Peñaranda: CoCooN, Ghent University
Jolien Dendooven: CoCooN, Ghent University
Christophe Detavernier: CoCooN, Ghent University
David Schaubroeck: imec and Ghent University
Nico Boon: Ghent University
Roel Baets: Ghent University-imec
Nicolas Le Thomas: Ghent University-imec

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract Ultra-violet (UV) light has still a limited scope in optical microscopy despite its potential advantages over visible light in terms of optical resolution and of interaction with a wide variety of biological molecules. The main challenge is to control in a robust, compact and cost-effective way UV light beams at the level of a single optical spatial mode and concomitantly to minimize the light propagation loss. To tackle this challenge, we present here photonic integrated circuits made of aluminum oxide thin layers that are compatible with both UV light and high-volume manufacturing. These photonic circuits designed at a wavelength of 360 nm enable super-resolved structured illumination microscopy with conventional wide-field microscopes and without modifying the usual protocol for handling the object to be imaged. As a biological application, we show that our UV photonic chips enable to image the autofluorescence of yeast cells and reveal features unresolved with standard wide-field microscopy.

Date: 2022
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DOI: 10.1038/s41467-022-31989-8

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