ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19

Maik Pietzner (), Robert Lorenz Chua, Eleanor Wheeler, Katharina Jechow, Julian D. S. Willett, Helena Radbruch, Saskia Trump, Bettina Heidecker, Hugo Zeberg, Frank L. Heppner, Roland Eils, Marcus A. Mall, J. Brent Richards, Leif-Erik Sander, Irina Lehmann, Sören Lukassen, Nicholas J. Wareham, Christian Conrad () and Claudia Langenberg ()
Additional contact information
Maik Pietzner: Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
Robert Lorenz Chua: Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
Eleanor Wheeler: MRC Epidemiology Unit, University of Cambridge
Katharina Jechow: Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
Julian D. S. Willett: McGill University
Helena Radbruch: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin und Humboldt-Universität zu Berlin
Saskia Trump: Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
Bettina Heidecker: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin und Humboldt-Universität zu Berlin
Hugo Zeberg: Max Planck Institute for Evolutionary Anthropology
Frank L. Heppner: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin und Humboldt-Universität zu Berlin
Roland Eils: Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
Marcus A. Mall: German Center for Lung Research (DZL), associated partner site
J. Brent Richards: McGill University
Leif-Erik Sander: Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH)
Irina Lehmann: Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
Sören Lukassen: Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
Nicholas J. Wareham: MRC Epidemiology Unit, University of Cambridge
Christian Conrad: Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
Claudia Langenberg: Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Despite two years of intense global research activity, host genetic factors that predispose to a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise eight robust (e.g., ELF5) or suggestive but unreported (e.g., RAB2A) candidate protein mediators of COVID-19 outcomes by integrating results from the COVID-19 Host Genetics Initiative with population-based plasma proteomics using statistical colocalisation. The transcription factor ELF5 (ELF5) shows robust and directionally consistent associations across different outcome definitions, including a >4-fold higher risk (odds ratio: 4.88; 95%-CI: 2.47–9.63; p-value

Date: 2022
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DOI: 10.1038/s41467-022-31999-6

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